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Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence
Joint Authors
Geng, Shan
Mu, Xin-Yi
Chen, Xiong-Bin
Hou, Ji-Ying
Jia, Dao-Yong
Xu, Chun-Yan
Wang, Ya-Ping
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-27
Country of Publication
Egypt
No. of Pages
10
Abstract EN
The researches in the dynamic changes of the progress of HSCs aging are very limited and necessary.
In this study, male C57BL/6 mice were divided into 5 groups by age.
We found that the superoxide damage of HSPCs started to increase from the middle age (6 months old), with notably reduced antioxidation ability.
In accordance with that, the senescence of HSPCs also started from the middle age, since the self-renewal and differentiation ability remarkably decreased, and senescence-associated markers SA-β-GAL increased in the 6-month-old and the older groups.
Interestingly, the telomere length and telomerase activity increased to a certain degree in the 6-month-old group.
It suggested an intrinsic spontaneous ability of HSPCs against aging.
It may provide a theoretical and experimental foundation for better understanding the senescence progress of HSPCs.
And the dynamic biological characteristics of HSPCs senescence may also contribute to the clinical optimal time for antiaging drug intervention.
American Psychological Association (APA)
Geng, Shan& Mu, Xin-Yi& Chen, Xiong-Bin& Hou, Ji-Ying& Jia, Dao-Yong& Xu, Chun-Yan…[et al.]. 2015. Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence. Stem Cells International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1076393
Modern Language Association (MLA)
Geng, Shan…[et al.]. Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence. Stem Cells International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1076393
American Medical Association (AMA)
Geng, Shan& Mu, Xin-Yi& Chen, Xiong-Bin& Hou, Ji-Ying& Jia, Dao-Yong& Xu, Chun-Yan…[et al.]. Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1076393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076393