SDF-1CXCR4 Axis Promotes MSCs to Repair Liver Injury Partially through Trans-Differentiation and Fusion with Hepatocytes
Joint Authors
Hao, Ning-Bo
Tang, Bo
Li, Chang-Zhu
Lü, Mu-Han
Wang, Su-Min
Wu, Yu-Yun
Liang, Guang-Ping
Yang, Shi-Ming
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-02
Country of Publication
Egypt
No. of Pages
10
Abstract EN
MSCs have become a popular target for developing end-stage liver therapies.
In this study, two models of bone marrow chimeric mice were used to construct the liver failure models.
Then it was found that MSCs can transdifferentiate into hepatocyte-like cells and these hepatocyte-like cells can significantly express albumin.
Furthermore it was also found that MSCs can fuse with the hepatocytes and these cells had the proliferation activity.
However, the percentage of transdifferentiation was significantly higher than fusion.
So it was considered that MSCs which transdifferentiated into hepatocyte-likes cells played important roles for repairing the injuring liver function.
American Psychological Association (APA)
Hao, Ning-Bo& Li, Chang-Zhu& Lü, Mu-Han& Tang, Bo& Wang, Su-Min& Wu, Yu-Yun…[et al.]. 2015. SDF-1CXCR4 Axis Promotes MSCs to Repair Liver Injury Partially through Trans-Differentiation and Fusion with Hepatocytes. Stem Cells International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1076399
Modern Language Association (MLA)
Hao, Ning-Bo…[et al.]. SDF-1CXCR4 Axis Promotes MSCs to Repair Liver Injury Partially through Trans-Differentiation and Fusion with Hepatocytes. Stem Cells International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1076399
American Medical Association (AMA)
Hao, Ning-Bo& Li, Chang-Zhu& Lü, Mu-Han& Tang, Bo& Wang, Su-Min& Wu, Yu-Yun…[et al.]. SDF-1CXCR4 Axis Promotes MSCs to Repair Liver Injury Partially through Trans-Differentiation and Fusion with Hepatocytes. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1076399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076399