Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy
Joint Authors
Vandergriff, Adam C.
de Andrade, James Bizetto Meira
Tang, Junnan
Hensley, M. Taylor
Caranasos, Thomas G.
Cheng, Ke
Piedrahita, Jorge A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-17
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Despite the efficacy of cardiac stem cells (CSCs) for treatment of cardiomyopathies, there are many limitations to stem cell therapies.
CSC-derived exosomes (CSC-XOs) have been shown to be responsible for a large portion of the regenerative effects of CSCs.
Using a mouse model of doxorubicin induced dilated cardiomyopathy, we study the effects of systemic delivery of human CSC-XOs in mice.
Mice receiving CSC-XOs showed improved heart function via echocardiography, as well as decreased apoptosis and fibrosis.
In spite of using immunocompetent mice and human CSC-XOs, mice showed no adverse immune reaction.
The use of CSC-XOs holds promise for overcoming the limitations of stem cells and improving cardiac therapies.
American Psychological Association (APA)
Vandergriff, Adam C.& de Andrade, James Bizetto Meira& Tang, Junnan& Hensley, M. Taylor& Piedrahita, Jorge A.& Caranasos, Thomas G.…[et al.]. 2015. Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy. Stem Cells International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1076405
Modern Language Association (MLA)
Vandergriff, Adam C.…[et al.]. Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy. Stem Cells International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1076405
American Medical Association (AMA)
Vandergriff, Adam C.& de Andrade, James Bizetto Meira& Tang, Junnan& Hensley, M. Taylor& Piedrahita, Jorge A.& Caranasos, Thomas G.…[et al.]. Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1076405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076405