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Diverse Cell Populations Involved in Regeneration of Renal Tubular Epithelium following Acute Kidney Injury
Joint Authors
Nojima, Yoshihisa
Takahashi, Shunsuke
Nakasatomi, Masao
Maeshima, Akito
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Renal tubular epithelium has the capacity to regenerate, repair, and reepithelialize in response to a variety of insults.
Previous studies with several kidney injury models demonstrated that various growth factors, transcription factors, and extracellular matrices are involved in this process.
Surviving tubular cells actively proliferate, migrate, and differentiate in the kidney regeneration process after injury, and some cells express putative stem cell markers or possess stem cell properties.
Using fate mapping techniques, bone marrow-derived cells and endothelial progenitor cells have been shown to transdifferentiate into tubular components in vivo or ex vivo.
Similarly, it has been demonstrated that, during tubular cell regeneration, several inflammatory cell populations migrate, assemble around tubular cells, and interact with tubular cells during the repair of tubular epithelium.
In this review, we describe recent advances in understanding the regeneration mechanisms of renal tubules, particularly the characteristics of various cell populations contributing to tubular regeneration, and highlight the targets for the development of regenerative medicine for treating kidney diseases in humans.
American Psychological Association (APA)
Maeshima, Akito& Takahashi, Shunsuke& Nakasatomi, Masao& Nojima, Yoshihisa. 2015. Diverse Cell Populations Involved in Regeneration of Renal Tubular Epithelium following Acute Kidney Injury. Stem Cells International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1076413
Modern Language Association (MLA)
Maeshima, Akito…[et al.]. Diverse Cell Populations Involved in Regeneration of Renal Tubular Epithelium following Acute Kidney Injury. Stem Cells International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1076413
American Medical Association (AMA)
Maeshima, Akito& Takahashi, Shunsuke& Nakasatomi, Masao& Nojima, Yoshihisa. Diverse Cell Populations Involved in Regeneration of Renal Tubular Epithelium following Acute Kidney Injury. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1076413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076413