Appraisal of Total Phenol, Flavonoid Contents, and Antioxidant Potential of Folkloric Lannea coromandelica Using In Vitro and In Vivo Assays
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The aim of this study was to determine the impending antioxidant properties of different extracts of crude methanolic extract (CME) of leaves of Lannea coromandelica (L.
coromandelica) and its two ethyl acetate (EAF) and aqueous (AqF) subfractions by employing various established in vitro systems and estimation of total phenolic and flavonoid content.
The results showed that extract and fractions possessed strong antioxidant activity in vitro and among them, EAF had the strongest antioxidant activity.
EAF was confirmed for its highest phenolic content, total flavonoid contents, and total antioxidant capacity.
The EAF was found to show remarkable scavenging activity on 2,2-diphenylpicrylhydrazyl (DPPH) (EC50 63.9 ± 0.64 µg/mL), superoxide radical (EC50 8.2 ± 0.12 mg/mL), and Fe2+ chelating activity (EC50 6.2 ± 0.09 mg/mL).
Based on our in vitro results, EAF was investigated for in vivo antioxidant assay.
Intragastric administration of the EAF can significantly increase levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GSH-Px) levels, and decrease malondialdehyde (MDA) content in the liver and kidney of CCl4-intoxicated rats.
These new evidences show that L.
coromandelica bared antioxidant activity.
American Psychological Association (APA)
Kumar, Tekeshwar& Jain, Vishal. 2015. Appraisal of Total Phenol, Flavonoid Contents, and Antioxidant Potential of Folkloric Lannea coromandelica Using In Vitro and In Vivo Assays. Scientifica،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1076432
Modern Language Association (MLA)
Kumar, Tekeshwar& Jain, Vishal. Appraisal of Total Phenol, Flavonoid Contents, and Antioxidant Potential of Folkloric Lannea coromandelica Using In Vitro and In Vivo Assays. Scientifica No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1076432
American Medical Association (AMA)
Kumar, Tekeshwar& Jain, Vishal. Appraisal of Total Phenol, Flavonoid Contents, and Antioxidant Potential of Folkloric Lannea coromandelica Using In Vitro and In Vivo Assays. Scientifica. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1076432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076432