CYP2A6 Polymorphisms May Strengthen Individualized Treatment for Nicotine Dependence
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Each CYP2A6 gene variant metabolizes nicotine differently depending on its enzymatic activities.
The normal nicotine metabolizer CYP2A6*1A is associated with high scores of nicotine dependence (5–10) on the Fagerström Test for Nicotine Dependence (FTND) scale because it encodes for enzymes that catalyze nicotine 100%.
Slow nicotine metabolizers (i.e., CYP2A6*1H, CYP2A6*4A, CYP2A6*9, and CYP2A6*12A) are associated with underrated nicotine metabolizing activity (50%–75%), linking them to low scores for nicotine dependence (0–4) on the FTND scale.
In a clinical trial involving the use of bupropion, people who were carriers of slow nicotine metabolizers were found to have a tendency to maintain abstinence 1.7 times longer than people with normal nicotine metabolizers.
An overview of CYP2A6 polymorphism enzymatic activities in nicotine dependence etiology and treatment revealed that slow nicotine metabolizers may strengthen the individualized treatment of nicotine dependence.
American Psychological Association (APA)
Akrodou, Yawo Mawuli. 2015. CYP2A6 Polymorphisms May Strengthen Individualized Treatment for Nicotine Dependence. Scientifica،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1076450
Modern Language Association (MLA)
Akrodou, Yawo Mawuli. CYP2A6 Polymorphisms May Strengthen Individualized Treatment for Nicotine Dependence. Scientifica No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1076450
American Medical Association (AMA)
Akrodou, Yawo Mawuli. CYP2A6 Polymorphisms May Strengthen Individualized Treatment for Nicotine Dependence. Scientifica. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1076450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076450