Macrophage Heterogeneity and Plasticity: Impact of Macrophage Biomarkers on Atherosclerosis
Joint Authors
Martínez, María Sofía
Salazar, Juan
Palmar, Jim
Bautista, Jordan
Gómez, Alexis
Bermúdez, Valmore
Chávez, Mervin
Rojas, Joselyn
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Cardiovascular disease (CVD) is a global epidemic, currently representing the worldwide leading cause of morbidity and mortality.
Atherosclerosis is the fundamental pathophysiologic component of CVD, where the immune system plays an essential role.
Monocytes and macrophages are key mediators in this aspect: due to their heterogeneity and plasticity, these cells may act as either pro- or anti-inflammatory mediators.
Indeed, monocytes may develop heterogeneous functional phenotypes depending on the predominating pro- or anti-inflammatory microenvironment within the lesion, resulting in classic, intermediate, and non-classic monocytes, each with strikingly differing features.
Similarly, macrophages may also adopt heterogeneous profiles being mainly M1 and M2, the former showing a proinflammatory profile while the latter demonstrates anti-inflammatory traits; they are further subdivided in several subtypes with more specialized functions.
Furthermore, macrophages may display plasticity by dynamically shifting between phenotypes in response to specific signals.
Each of these distinct cell profiles is associated with diverse biomarkers which may be exploited for therapeutic intervention, including IL-10, IL-13, PPAR-γ, LXR, NLRP3 inflammasomes, and microRNAs.
Direct modulation of the molecular pathways concerning these potential macrophage-related targets represents a promising field for new therapeutic alternatives in atherosclerosis and CVD.
American Psychological Association (APA)
Rojas, Joselyn& Salazar, Juan& Martínez, María Sofía& Palmar, Jim& Bautista, Jordan& Chávez, Mervin…[et al.]. 2015. Macrophage Heterogeneity and Plasticity: Impact of Macrophage Biomarkers on Atherosclerosis. Scientifica،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1076463
Modern Language Association (MLA)
Rojas, Joselyn…[et al.]. Macrophage Heterogeneity and Plasticity: Impact of Macrophage Biomarkers on Atherosclerosis. Scientifica No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1076463
American Medical Association (AMA)
Rojas, Joselyn& Salazar, Juan& Martínez, María Sofía& Palmar, Jim& Bautista, Jordan& Chávez, Mervin…[et al.]. Macrophage Heterogeneity and Plasticity: Impact of Macrophage Biomarkers on Atherosclerosis. Scientifica. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1076463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076463