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Nasal Expiratory Positive Airway Pressure Devices (Provent) for OSA: A Systematic Review and Meta-Analysis
Joint Authors
Zaghi, Soroush
Camacho, Macario
Riaz, Muhammad
Certal, Victor
Kushida, Clete A.
Nigam, Gaurav
Abdullatif, Jose
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-21
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Objective.
To quantify the effectiveness of nasal expiratory positive airway pressure (nasal EPAP) devices or Provent as treatment for obstructive sleep apnea (OSA).
Methods.
PubMed and six other databases were searched through November 15, 2015, without language limitations.
Results.
Eighteen studies (920 patients) were included.
Pre- and post-nasal EPAP means ± standard deviations (M ± SD) for apnea-hypopnea index (AHI) in 345 patients decreased from 27.32±22.24 to 12.78±16.89 events/hr (relative reduction = 53.2%).
Random effects modeling mean difference (MD) was −14.78 events/hr [95% CI −19.12, −10.45], p value < 0.00001.
Oxygen desaturation index (ODI) in 247 patients decreased from 21.2±19.3 to 12.4±14.1 events/hr (relative reduction = 41.5%, p value < 0.00001).
Lowest oxygen saturation (LSAT) M ± SD improved in 146 patients from 83.2±6.8% to 86.2±11.1%, MD 3 oxygen saturation points [95% CI 0.57, 5.63].
Epworth Sleepiness Scale (ESS) M ± SD improved (359 patients) from 9.9±5.3 to 7.4±5.0, MD −2.5 [95% CI −3.2, −1.8], p value < 0.0001.
Conclusion.
Nasal EPAP (Provent) reduced AHI by 53.2%, ODI by 41.5% and improved LSAT by 3 oxygen saturation points.
Generally, there were no clear characteristics (demographic factors, medical history, and/or physical exam finding) that predicted favorable response to these devices.
However, limited evidence suggests that high nasal resistance could be associated with treatment failure.
Additional studies are needed to identify demographic and polysomnographic characteristics that would predict therapeutic success with nasal EPAP (Provent).
American Psychological Association (APA)
Riaz, Muhammad& Certal, Victor& Nigam, Gaurav& Abdullatif, Jose& Zaghi, Soroush& Kushida, Clete A.…[et al.]. 2015. Nasal Expiratory Positive Airway Pressure Devices (Provent) for OSA: A Systematic Review and Meta-Analysis. Sleep Disorders،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1076493
Modern Language Association (MLA)
Riaz, Muhammad…[et al.]. Nasal Expiratory Positive Airway Pressure Devices (Provent) for OSA: A Systematic Review and Meta-Analysis. Sleep Disorders No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1076493
American Medical Association (AMA)
Riaz, Muhammad& Certal, Victor& Nigam, Gaurav& Abdullatif, Jose& Zaghi, Soroush& Kushida, Clete A.…[et al.]. Nasal Expiratory Positive Airway Pressure Devices (Provent) for OSA: A Systematic Review and Meta-Analysis. Sleep Disorders. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1076493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076493