The Application of GeneXpert MTBRIF for Smear-Negative TB Diagnosis as a Fee-Paying Service at a South Asian General Hospital
Joint Authors
Shrestha, Poojan
Arjyal, Amit
Caws, Maxine
Prajapati, Krishna Govinda
Karkey, Abhilasha
Dongol, Sabina
Pathak, Saruna
Prajapati, Shanti
Basnyat, Buddha
Source
Tuberculosis Research and Treatment
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The GeneXpert MTB/RIF assay (Xpert) is a novel automated diagnostic tool for tuberculosis but its optimal placement in the healthcare system has not been determined.
The objective of this study was to determine the possibility of additional case detection for pulmonary tuberculosis (PTB) by offering Xpert to smear-negative patients in a low-HIV burden setting with no Mycobacterium tuberculosis (M.tb.) culture facilities.
Patients routinely presenting with symptoms suggestive of PTB with negative smears were offered single Xpert test on a fee-paying basis.
Data were retrospectively reviewed to determine case detection in patients tested from February to December 2013.
Symptoms associated with a positive test were analysed to determine if refinement of clinical criteria would reduce unnecessary testing.
258 smear-negative patients were included and M.tb.
was detected in 55 (21.32%, n=55/258).
Using standard clinical assessment for selection, testing 5 patients detected one case of smear-negative PTB.
These results demonstrate that fee-paying Xpert service in low-income setting can increase TB case confirmation substantially and further systematic studies of health economic implications should be conducted to determine optimal implementation models to increase access to Xpert in low- and middle-income countries.
American Psychological Association (APA)
Shrestha, Poojan& Arjyal, Amit& Caws, Maxine& Prajapati, Krishna Govinda& Karkey, Abhilasha& Dongol, Sabina…[et al.]. 2015. The Application of GeneXpert MTBRIF for Smear-Negative TB Diagnosis as a Fee-Paying Service at a South Asian General Hospital. Tuberculosis Research and Treatment،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1078430
Modern Language Association (MLA)
Shrestha, Poojan…[et al.]. The Application of GeneXpert MTBRIF for Smear-Negative TB Diagnosis as a Fee-Paying Service at a South Asian General Hospital. Tuberculosis Research and Treatment No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1078430
American Medical Association (AMA)
Shrestha, Poojan& Arjyal, Amit& Caws, Maxine& Prajapati, Krishna Govinda& Karkey, Abhilasha& Dongol, Sabina…[et al.]. The Application of GeneXpert MTBRIF for Smear-Negative TB Diagnosis as a Fee-Paying Service at a South Asian General Hospital. Tuberculosis Research and Treatment. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1078430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1078430