Change of Scaling-Induced Proinflammatory Cytokine on the Clinical Efficacy of Periodontitis Treatment

Abstract EN

Proinflammatory cytokines are key inflammatory mediators in periodontitis.

This studyaimed to investigate the relationship between proinflammatory cytokines in saliva and periodontalstatus.

To investigate the usefulness of cytokines in the therapeutic approach for periodontaldisease, the relationship between stimulated cytokine changes and the periodontitis treatmentoutcome was investigated in this study.

Saliva was obtained from 22 patients diagnosed bydentists as having chronic periodontitis.

The proinflammatory cytokine (interleukin-1 α (IL-1 α ),interleukin-1 β (IL-1 β ), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor α (TNF- α ), and tumor necrosis factor β (TNF- β )) levels were determined using a commercially available kit.

The IL-1 β and IL-6 levels increased, whereas the TNF- β levels decreased with the severity of periodontitis (4 mm pocket percentage).

Poststimulation IL-1 α , IL-6, and IL-8 levels were higher in patients who had an improved treatment outcome.

The differences of IL-6 levels (cutpoint: 0.05 μg/g) yielded a sensitivity and specificity of 90.0% and 81.82%, respectively, forpredicting the periodontitis treatment outcome.

Among the proinflammatory cytokines, stimulatedIL-6 was an excellent marker for predicting the periodontitis treatment outcome.