Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer
Joint Authors
Iida, Miho
Tominaga, Eiichiro
Banno, Kouji
Kobayashi, Yusuke
Irie, Haruko
Yanokura, Megumi
Masuda, Kenta
Aoki, Daisuke
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The goals of drug repositioning are to find a new pharmacological effect of a drug for which human safety and pharmacokinetics are established and to expand the therapeutic range of the drug to another disease.
Such drug discovery can be performed at low cost and in the short term based on the results of previous clinical trials.
New drugs for gynecologic tumors may be found by drug repositioning.
For example, PPAR ligands may be effective against ovarian cancer, since PPAR activation eliminates COX-2 expression, arrests the cell cycle, and induces apoptosis.
Metformin, an antidiabetic drug, is effective for endometrial cancer through inhibition of the PI3K-Akt-mTOR pathway by activating LKB1-AMPK and reduction of insulin and insulin-like growth factor-1 due to AMPK activation.
COX-2 inhibitors for cervical cancer may also be examples of drug repositioning.
PGE2 is induced in the arachidonate cascade by COX-2.
PGE2 maintains high expression of COX-2 and induces angiogenic factors including VEGF and bFGF, causing carcinogenesis.
COX-2 inhibitors suppress these actions and inhibit carcinogenesis.
Combination therapy using drugs found by drug repositioning and current anticancer drugs may increase efficacy and reduce adverse drug reactions.
Thus, drug repositioning may become a key approach for gynecologic cancer in drug discovery.
American Psychological Association (APA)
Banno, Kouji& Iida, Miho& Yanokura, Megumi& Irie, Haruko& Masuda, Kenta& Kobayashi, Yusuke…[et al.]. 2015. Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1078683
Modern Language Association (MLA)
Banno, Kouji…[et al.]. Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer. The Scientific World Journal No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1078683
American Medical Association (AMA)
Banno, Kouji& Iida, Miho& Yanokura, Megumi& Irie, Haruko& Masuda, Kenta& Kobayashi, Yusuke…[et al.]. Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1078683
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1078683