Effects of 5-Amyno-4-(1,3-benzothyazol-2-yn)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one Intake on Digestive System in a Rat Model of Colon Cancer
Joint Authors
Kuznietsova, Halyna M.
Luzhenetska, Valentyna K.
Kotlyar, Iryna P.
Rybalchenko, Volodymyr K.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Introduction.
Pyrrol derivate 5-amyno-4-(1,3-benzothyazol-2-yn)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one (D1) has shown antiproliferative activities in vitro, so investigation of the impact of D1 intake on gut organs in rats that experienced colon cancer seems to be necessary.
Materials and Methods.
D1 at the dose of 2.3 mg/kg was administered per os daily for 27 (from the 1st day of experiment) or 7 (from the 21st week of experiment) weeks to rats that experienced 1,2-dimethylhydrazine (DMH)-induced colon cancer for 20 weeks.
5-Fluorouracil (5FU) was chosen as reference drug and was administered intraperitoneally weekly for 7 weeks (from the 21st week of experiment) at the dose of 45 mg/kg.
Results.
Antitumor activity of D1 comparable with the 5FU one against DMH-induced colon cancer in rats was observed (decrease of tumor number and tumor total area up to 46%).
D1 attenuated the inflammation of colon, gastric and jejunal mucosa, and the liver, caused by DMH, unlike 5FU, aggravating the latter.
In addition, D1 partially normalized mucosa morphometric parameters suggesting its functional restore.
Conclusions.
D1 possesses, comparable with 5-fluorouracil antitumor efficacy, less damaging effects on the tissues beyond cancerous areas and contributes to partial morphological and functional gut organs recovery.
American Psychological Association (APA)
Kuznietsova, Halyna M.& Luzhenetska, Valentyna K.& Kotlyar, Iryna P.& Rybalchenko, Volodymyr K.. 2015. Effects of 5-Amyno-4-(1,3-benzothyazol-2-yn)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one Intake on Digestive System in a Rat Model of Colon Cancer. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1078716
Modern Language Association (MLA)
Kuznietsova, Halyna M.…[et al.]. Effects of 5-Amyno-4-(1,3-benzothyazol-2-yn)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one Intake on Digestive System in a Rat Model of Colon Cancer. The Scientific World Journal No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1078716
American Medical Association (AMA)
Kuznietsova, Halyna M.& Luzhenetska, Valentyna K.& Kotlyar, Iryna P.& Rybalchenko, Volodymyr K.. Effects of 5-Amyno-4-(1,3-benzothyazol-2-yn)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one Intake on Digestive System in a Rat Model of Colon Cancer. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1078716
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1078716