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Efficacy and Safety of Miltefosine in Treatment of Post-Kala-Azar Dermal Leishmaniasis
Joint Authors
Sundar, Shyam
Singh, Anup
Chakravarty, Jaya
Rai, Madhukar
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Long regimens for the treatment of post-kala-azar dermal leishmaniasis (PKDL) result in noncompliance.
A safe, effective, and acceptable regimen for the treatment of PKDL is still to be developed.
Miltefosine has been found to be effective in the treatment of Visceral Leishmaniasis (VL).
Hence, its efficacy was tested in patients of PKDL.
Methods.
In this exploratory study, 33 patients with PKDL aged 10 years and above were administered miltefosine (50 mg for those weighing <25 kg or 100 mg in divided doses for those ≥25 kg and 2.5 mg per kg for children) for 12 weeks and followed up for one year to find out the efficacy.
Results.
Out of 33 patients, 3 patients withdrew consent.
Treatment was stopped due to adverse effect in 1 patient.
28 (96.6%) got cured with complete disappearance of lesion while 1 patient (3.4%) failed treatment by protocol analysis.
Conclusion.
Miltefosine was found to be effective and safe in the treatment of PKDL.
American Psychological Association (APA)
Sundar, Shyam& Singh, Anup& Chakravarty, Jaya& Rai, Madhukar. 2015. Efficacy and Safety of Miltefosine in Treatment of Post-Kala-Azar Dermal Leishmaniasis. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1078746
Modern Language Association (MLA)
Sundar, Shyam…[et al.]. Efficacy and Safety of Miltefosine in Treatment of Post-Kala-Azar Dermal Leishmaniasis. The Scientific World Journal No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1078746
American Medical Association (AMA)
Sundar, Shyam& Singh, Anup& Chakravarty, Jaya& Rai, Madhukar. Efficacy and Safety of Miltefosine in Treatment of Post-Kala-Azar Dermal Leishmaniasis. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1078746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1078746