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Effect of In Vitro Transcorneal Approach of Aceclofenac Eye Drops through Excised Goat, Sheep, and Buffalo Corneas
Joint Authors
Paliwal, Sarvesh
Dave, Vivek
Yadav, Sachdev
Sharma, Swapnil
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The current study involves the evaluation of factors that influence the transcorneal permeation of aqueous drops of aceclofenac ophthalmic formulation through freshly excised goat, sheep, and buffalo corneas.
Aceclofenac formulation with different concentrations 0.1–0.5% (w/v) and with different pH and different preservatives, was taken into account.
The amount of drug permeated from different formulations was estimated using an Franz diffusion cell.
A linear increase in drug permeation was observed with increase in pH (5.5 to 7.4).
The apparent permeability coefficient was found to be maximum 15.01 ± 0.45 on goat cornea and maximum transport of aceclofenac was observed at physiological pH of tears (i.e., 7).
The results advocate that aceclofenac 0.5% (w/v) ophthalmic solution (pH 7.0) containing BAK (0.01%) provides maximum in vitro ocular permeability through goat, sheep, and buffalo corneas.
American Psychological Association (APA)
Dave, Vivek& Paliwal, Sarvesh& Yadav, Sachdev& Sharma, Swapnil. 2015. Effect of In Vitro Transcorneal Approach of Aceclofenac Eye Drops through Excised Goat, Sheep, and Buffalo Corneas. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1078765
Modern Language Association (MLA)
Dave, Vivek…[et al.]. Effect of In Vitro Transcorneal Approach of Aceclofenac Eye Drops through Excised Goat, Sheep, and Buffalo Corneas. The Scientific World Journal No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1078765
American Medical Association (AMA)
Dave, Vivek& Paliwal, Sarvesh& Yadav, Sachdev& Sharma, Swapnil. Effect of In Vitro Transcorneal Approach of Aceclofenac Eye Drops through Excised Goat, Sheep, and Buffalo Corneas. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1078765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1078765