Effect of fenugreek on carbohydrate and lipid metabolisms of rats treated with cypermethr in combined with high-fat-diet and low dosestreptozotosin

Abstract EN

The aim of the present study was to use the new model for the type 2 diabetes using high-fat diet (HFD) in combination with low dose of streptozotosin (STZ, 35mg/kg) and investgate the influences of cypermethr in (pesticide) toxicity which attenuated by fenugreek soaked seeds, etiolated sprouts (3 days old) and microgreen (10 days old) semi-modified diet (SMD) on experimental rats.

From the obtained results, it can be indicated that the high fat feeding in combination with a low doses of STZ together with cypermthrin ingestion increased blood glucose and LDL-c in the paralled with decreasing rats body weight gain.

The treatment by fenugreek etiolated sprouts (10% ) semi-modified diet for HFD with STZ as semi-modified diets improved significantly the rats body weight gain (BWG) and lipids profile, while feeding on fenugreek microgreen readjusted significantly blood glucose, BWG, total cholesterol and HDL-c but decreased LDL-c levels.

On the other hand, the using of soaked fenugreek seed semi-modified diets increased only BWG but decreased LDL-c.

The hyperglycemia increased the total cholesterol content under the treatment with fenugreek microgreen semi-modified diets which showed more pronounced increment in combination with cypermethrin.

The accomplished results showed that cypermethrin led to a hyperglycemic activity in HFD/STZ model rats.

Soaking fenugreek seeds improved lipid metabolism compared with fenugreek and microgreen which non-toxic in doses given to rats in the present study over 28 days period.