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Morphine for the Treatment of Pain in Sickle Cell Disease
Joint Authors
Ballas, Samir K.
Gupta, Mihir
Msambichaka, Lilian
Gupta, Kalpna
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Pain is a hallmark of sickle cell disease (SCD) and its treatment remains challenging.
Opioids are the major family of analgesics that are commonly used for treating severe pain.
However, these are not always effective and are associated with the liabilities of their own.
The pharmacology and multiorgan side effects of opioids are rapidly emerging areas of investigation, but there remains a scarcity of clinical studies.
Due to opioid-induced endothelial-, mast cell-, renal mesangial-, and epithelial-cell-specific effects and proinflammatory as well as growth influencing signaling, it is likely that when used for analgesia, opioids may have organ specific pathological effects.
Experimental and clinical studies, even though extremely few, suggest that opioids may exacerbate existent organ damage and also stimulate pathologies of their own.
Because of the recurrent and/or chronic use of large doses of opioids in SCD, it is critical to evaluate the role and contribution of opioids in many complications of SCD.
The aim of this review is to initiate inquiry to develop strategies that may prevent the inadvertent effect of opioids on organ function in SCD, should it occur, without compromising analgesia.
American Psychological Association (APA)
Gupta, Mihir& Msambichaka, Lilian& Ballas, Samir K.& Gupta, Kalpna. 2015. Morphine for the Treatment of Pain in Sickle Cell Disease. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1078877
Modern Language Association (MLA)
Gupta, Mihir…[et al.]. Morphine for the Treatment of Pain in Sickle Cell Disease. The Scientific World Journal No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1078877
American Medical Association (AMA)
Gupta, Mihir& Msambichaka, Lilian& Ballas, Samir K.& Gupta, Kalpna. Morphine for the Treatment of Pain in Sickle Cell Disease. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1078877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1078877