Lack of Association between rs2067474 Polymorphism in Histamine Receptor H2 Gene and Breast Cancer in Chinese Han Population
Joint Authors
Cai, Wen-Ke
Zhang, Jia-Bin
Wang, Niu-Min
Wang, Ying-Lin
Zhao, Can-Hu
Lu, Jun
He, Gong-Hao
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Histamine H2 receptor (HRH2) was previously suggested to affect the proliferation of breast cancer cells and disease-free survival of breast cancer patients.
Furthermore, a common polymorphism, rs2067474, was identified in an enhancer element of the HRH2 gene promoter and was reported to be associated with various diseases including cancer.
However, the relationship between this polymorphism and breast cancer risk and malignant degree remains unclear.
The aim of this study was to clarify the clinical association of rs2067474 polymorphism with breast cancer.
A total of 201 unrelated Chinese Han breast cancer patients and 238 ethnicity-matched health controls were recruited and rs2067474 polymorphism was genotyped.
Logistic regression analyses were performed to calculate the odds ratios (ORs) as a measure of association of genotype with breast cancer according to 3 genetic models (dominant, recessive, and additive).
Although the percentage of hormone receptor negative cases tended to be higher in AA genotypes, we did not find any significant associations of rs2067474 polymorphism with breast cancer risk or with related clinicopathological parameters in the present study, which indicates that rs2067474 polymorphism of HRH2 gene might not be a risk factor in the development of breast cancer in Chinese Han population.
American Psychological Association (APA)
Cai, Wen-Ke& Zhang, Jia-Bin& Wang, Niu-Min& Wang, Ying-Lin& Zhao, Can-Hu& Lu, Jun…[et al.]. 2015. Lack of Association between rs2067474 Polymorphism in Histamine Receptor H2 Gene and Breast Cancer in Chinese Han Population. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1078883
Modern Language Association (MLA)
Cai, Wen-Ke…[et al.]. Lack of Association between rs2067474 Polymorphism in Histamine Receptor H2 Gene and Breast Cancer in Chinese Han Population. The Scientific World Journal No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1078883
American Medical Association (AMA)
Cai, Wen-Ke& Zhang, Jia-Bin& Wang, Niu-Min& Wang, Ying-Lin& Zhao, Can-Hu& Lu, Jun…[et al.]. Lack of Association between rs2067474 Polymorphism in Histamine Receptor H2 Gene and Breast Cancer in Chinese Han Population. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1078883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1078883