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Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice
Joint Authors
Dinh, Chi H. L.
Szabo, Alexander
Yu, Yinghua
Camer, Danielle
Wang, Hongqin
Huang, Xu Feng
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-05
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Mesenteric fat belongs to visceral fat.
An increased deposition of mesenteric fat contributes to obesity associated complications such as type 2 diabetes and cardiovascular diseases.
We have investigated the therapeutic effects of bardoxolone methyl (BARD) on mesenteric adipose tissue of mice fed a high-fat diet (HFD).
Male C57BL/6J mice were administered oral BARD during HFD feeding (HFD/BARD), only fed a high-fat diet (HFD), or fed low-fat diet (LFD) for 21 weeks.
Histology and immunohistochemistry were used to analyse mesenteric morphology and macrophages, while Western blot was used to assess the expression of inflammatory, oxidative stress, and energy expenditure proteins.
Supplementation of drinking water with BARD prevented mesenteric fat deposition, as determined by a reduction in large adipocytes.
BARD prevented inflammation as there were fewer inflammatory macrophages and reduced proinflammatory cytokines (interleukin-1 beta and tumour necrosis factor alpha).
BARD reduced the activation of extracellular signal-regulated kinase (ERK) and Akt, suggesting an antioxidative stress effect.
BARD upregulates energy expenditure proteins, judged by the increased activity of tyrosine hydroxylase (TH) and AMP-activated protein kinase (AMPK) and increased peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), and uncoupling protein 2 (UCP2) proteins.
Overall, BARD induces preventive effect in HFD mice through regulation of mesenteric adipose tissue.
American Psychological Association (APA)
Dinh, Chi H. L.& Szabo, Alexander& Yu, Yinghua& Camer, Danielle& Wang, Hongqin& Huang, Xu Feng. 2015. Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1078888
Modern Language Association (MLA)
Dinh, Chi H. L.…[et al.]. Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice. The Scientific World Journal No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1078888
American Medical Association (AMA)
Dinh, Chi H. L.& Szabo, Alexander& Yu, Yinghua& Camer, Danielle& Wang, Hongqin& Huang, Xu Feng. Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1078888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1078888