Ultrastructural Analysis of Leishmania infantum chagasi Promastigotes Forms Treated In Vitro with Usnic Acid
Joint Authors
da Silva, Nicácio Henrique
Brayner, Fábio André
Alves, Luiz Carlos
da Luz, João S. B.
de Oliveira, Erwelly B.
Martins, Monica C. B.
da Silva, Luiz L. S.
Silva, Eliete C.
Medeiros, Paloma Lys de
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Leishmaniasis is considered by the World Health Organization as one of the infectious parasitic diseases endemic of great relevance and a global public health problem.
Pentavalent antimonials used for treatment of this disease are limited and new phytochemicals emerge as an alternative to existing treatments, due to the low toxicity and cost reduction.
Usnic acid is uniquely found in lichens and is especially abundant in genera such as Alectoria, Cladonia, Evernia, Lecanora, Ramalina, and Usnea.
Usnic acid has been shown to exhibit antiviral, antiprotozoal, antiproliferative, anti-inflammatory, and analgesic activity.
The aim of this study was to evaluate the antileishmanial activity of usnic acid on Leishmania infantum chagasi promastigotes and the occurrence of drug-induced ultrastructural damage in the parasite.
Usnic acid was effective against the promastigote forms (IC50 = 18.30 ± 2.00 µg/mL).
Structural and ultrastructural aspects of parasite were analyzed.
Morphological alterations were observed as blebs in cell membrane and shapes given off, increasing the number of cytoplasmic vacuoles, and cellular and mitochondrial swelling, with loss of cell polarity.
We concluded that the usnic acid presented antileishmanial activity against promastigote forms of Leishmania infantum chagasi and structural and ultrastructural analysis reinforces its cytotoxicity.
Further, in vitro studies are warranted to further evaluate this potential.
American Psychological Association (APA)
da Luz, João S. B.& de Oliveira, Erwelly B.& Martins, Monica C. B.& da Silva, Nicácio Henrique& Alves, Luiz Carlos& Brayner, Fábio André…[et al.]. 2015. Ultrastructural Analysis of Leishmania infantum chagasi Promastigotes Forms Treated In Vitro with Usnic Acid. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1078930
Modern Language Association (MLA)
da Luz, João S. B.…[et al.]. Ultrastructural Analysis of Leishmania infantum chagasi Promastigotes Forms Treated In Vitro with Usnic Acid. The Scientific World Journal No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1078930
American Medical Association (AMA)
da Luz, João S. B.& de Oliveira, Erwelly B.& Martins, Monica C. B.& da Silva, Nicácio Henrique& Alves, Luiz Carlos& Brayner, Fábio André…[et al.]. Ultrastructural Analysis of Leishmania infantum chagasi Promastigotes Forms Treated In Vitro with Usnic Acid. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1078930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1078930