Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of “Zapote” Pouteria mammosa (L.) Cronquist
Joint Authors
Dutok, Carlos M. S.
Berenguer-Rivas, Clara Azalea
Rodríguez-Leblanch, Elizabeth
Pérez-Jackson, Liliana
Chil-Nuñez, Idelsy
Escalona-Arranz, Julio César
Reyes-Tur, Bernardo
Queiroz, Margareth M. C.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The common use of Pouteria mammosa (L.) Cronquist, “Mamey or Zapote,” in food and ethnobotanic medicine shows its low or absent toxicity as fruit extracts prepared from seeds.
However, it is essential to conduct security trials to scientifically support their use in drug therapy.
This study evaluated the aqueous and hydroalcoholic extract (25%) Acute Oral Toxicity, obtained from the seeds of P.
mammosa, in Sprague Dawley rats and dermal and eye irritability in New Zealand rabbits.
The 404 and 405 acute dermal and eye irritation/corrosion guidelines were used, as well as the 423 Acute Oral Toxicity guideline, Acute Toxic Class Method of the Organization for Economic Cooperation and Development (OECD).
The aqueous extract was located in the following category: not classified as toxic (CTA 5), while hydroalcoholic extract at 25% was classified as dangerous (CTA 4).
Both extracts can be used without side reaction that irritates the skin which permitted classification as potentially not irritant.
P.
mammosa in the two extracts caused mild and reversible eye irritation, and it was classified as slightly irritating.
American Psychological Association (APA)
Dutok, Carlos M. S.& Berenguer-Rivas, Clara Azalea& Rodríguez-Leblanch, Elizabeth& Pérez-Jackson, Liliana& Chil-Nuñez, Idelsy& Escalona-Arranz, Julio César…[et al.]. 2015. Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of “Zapote” Pouteria mammosa (L.) Cronquist. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1078957
Modern Language Association (MLA)
Dutok, Carlos M. S.…[et al.]. Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of “Zapote” Pouteria mammosa (L.) Cronquist. The Scientific World Journal No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1078957
American Medical Association (AMA)
Dutok, Carlos M. S.& Berenguer-Rivas, Clara Azalea& Rodríguez-Leblanch, Elizabeth& Pérez-Jackson, Liliana& Chil-Nuñez, Idelsy& Escalona-Arranz, Julio César…[et al.]. Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of “Zapote” Pouteria mammosa (L.) Cronquist. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1078957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1078957