Development of PET and SPECT Probes for Glutamate Receptors
Joint Authors
Fuchigami, Takeshi
Nakayama, Morio
Yoshida, Sakura
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-22
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
l-Glutamate and its receptors (GluRs) play a key role in excitatory neurotransmission within the mammalian central nervous system (CNS).
Impaired regulation of GluRs has also been implicated in various neurological disorders.
GluRs are classified into two major groups: ionotropic GluRs (iGluRs), which are ligand-gated ion channels, and metabotropic GluRs (mGluRs), which are coupled to heterotrimeric guanosine nucleotide binding proteins (G-proteins).
Positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging of GluRs could provide a novel view of CNS function and of a range of brain disorders, potentially leading to the development of new drug therapies.
Although no satisfactory imaging agents have yet been developed for iGluRs, several PET ligands for mGluRs have been successfully employed in clinical studies.
This paper reviews current progress towards the development of PET and SPECT probes for GluRs.
American Psychological Association (APA)
Fuchigami, Takeshi& Nakayama, Morio& Yoshida, Sakura. 2015. Development of PET and SPECT Probes for Glutamate Receptors. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1079034
Modern Language Association (MLA)
Fuchigami, Takeshi…[et al.]. Development of PET and SPECT Probes for Glutamate Receptors. The Scientific World Journal No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1079034
American Medical Association (AMA)
Fuchigami, Takeshi& Nakayama, Morio& Yoshida, Sakura. Development of PET and SPECT Probes for Glutamate Receptors. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1079034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1079034