Development of PET and SPECT Probes for Glutamate Receptors

Joint Authors

Fuchigami, Takeshi
Nakayama, Morio
Yoshida, Sakura

Source

The Scientific World Journal

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-19, 19 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-03-22

Country of Publication

Egypt

No. of Pages

19

Main Subjects

Medicine
Information Technology and Computer Science

Abstract EN

l-Glutamate and its receptors (GluRs) play a key role in excitatory neurotransmission within the mammalian central nervous system (CNS).

Impaired regulation of GluRs has also been implicated in various neurological disorders.

GluRs are classified into two major groups: ionotropic GluRs (iGluRs), which are ligand-gated ion channels, and metabotropic GluRs (mGluRs), which are coupled to heterotrimeric guanosine nucleotide binding proteins (G-proteins).

Positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging of GluRs could provide a novel view of CNS function and of a range of brain disorders, potentially leading to the development of new drug therapies.

Although no satisfactory imaging agents have yet been developed for iGluRs, several PET ligands for mGluRs have been successfully employed in clinical studies.

This paper reviews current progress towards the development of PET and SPECT probes for GluRs.

American Psychological Association (APA)

Fuchigami, Takeshi& Nakayama, Morio& Yoshida, Sakura. 2015. Development of PET and SPECT Probes for Glutamate Receptors. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1079034

Modern Language Association (MLA)

Fuchigami, Takeshi…[et al.]. Development of PET and SPECT Probes for Glutamate Receptors. The Scientific World Journal No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1079034

American Medical Association (AMA)

Fuchigami, Takeshi& Nakayama, Morio& Yoshida, Sakura. Development of PET and SPECT Probes for Glutamate Receptors. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1079034

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1079034