The “Gender Factor” in Wearing-Off among Patients with Parkinson’s Disease: A Post Hoc Analysis of DEEP Study
Joint Authors
Colombo, Delia
Abbruzzese, Giovanni
Barone, Paolo
Franconi, Flavia
Attar, Mahmood
Zagni, Emanuela
Haggiag, Shalom
Stocchi, Fabrizio
Antonini, Angelo
Simoni, Lucia
Bellia, Gilberto
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background.
The early detection of wearing-off in Parkinson disease (DEEP) observational study demonstrated that women with Parkinson’s disease (PD) carry an increased risk (80.1%) for wearing-off (WO).
This post hoc analysis of DEEP study evaluates gender differences on WO and associated phenomena.
Methods.
Patients on dopaminergic treatment for ≥1 year were included in this multicenter observational cross-sectional study.
In a single visit, WO was diagnosed based on neurologist assessment as well as the use of the 19-item wearing-off questionnaire (WOQ-19); WO was defined for scores ≥2.
Post hoc analyses were conducted to investigate gender difference for demographic and clinical features with respect to WO.
Results.
Of 617 patients enrolled, 236 were women and 381 were men.
Prevalence of WO was higher among women, according to both neurologists’ judgment (61.9% versus 53.8%, P = 0.045 ) and the WOQ-19 analysis (72.5% versus 64.0%, P = 0.034 ).
In patients with WO (WOQ-19), women experienced ≥1 motor symptom in 72.5% versus 64.0% in men and ≥1 nonmotor symptom in 44.5% versus 36.7%, in men.
Conclusions.
Our results suggest WO as more common among women, for both motor and nonmotor symptoms.
Prospective studies are warranted to investigate this potential gender-effect.
American Psychological Association (APA)
Colombo, Delia& Abbruzzese, Giovanni& Antonini, Angelo& Barone, Paolo& Bellia, Gilberto& Franconi, Flavia…[et al.]. 2015. The “Gender Factor” in Wearing-Off among Patients with Parkinson’s Disease: A Post Hoc Analysis of DEEP Study. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1079146
Modern Language Association (MLA)
Colombo, Delia…[et al.]. The “Gender Factor” in Wearing-Off among Patients with Parkinson’s Disease: A Post Hoc Analysis of DEEP Study. The Scientific World Journal No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1079146
American Medical Association (AMA)
Colombo, Delia& Abbruzzese, Giovanni& Antonini, Angelo& Barone, Paolo& Bellia, Gilberto& Franconi, Flavia…[et al.]. The “Gender Factor” in Wearing-Off among Patients with Parkinson’s Disease: A Post Hoc Analysis of DEEP Study. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1079146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1079146