Theragnostic Imaging Using Radiolabeled Antibodies and Tyrosine Kinase Inhibitors
Joint Authors
Yoshimoto, Mitsuyoshi
Kurihara, Hiroaki
Fujii, Hirofumi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
During the past decade, the efficacy of new molecular targeted drugs such as tyrosine kinase inhibitors (TKIs) and monoclonal antibodies has been proven worldwide, and molecular targeted therapies have become the mainstream in cancer therapy.
However, clinical use of these new drugs presents unexpected adverse effects or poor therapeutic effects.
Therefore, we require diagnostic tools to estimate the target molecule status in cancer tissues and predict therapeutic efficacy and adverse effects.
Although immunohistochemical, polymerase chain reaction (PCR) and fluorescence in situ hybridization (FISH) analyses of biopsy samples are conventional and popular for this diagnostic purpose, molecular imaging modalities such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) are also useful for noninvasive estimation of gene and protein expression and drug pharmacokinetics.
In this review, we introduce new radiolabeled TKIs, antibodies, and their clinical application in molecular targeted therapy and discuss the issues of these imaging probes.
American Psychological Association (APA)
Yoshimoto, Mitsuyoshi& Kurihara, Hiroaki& Fujii, Hirofumi. 2015. Theragnostic Imaging Using Radiolabeled Antibodies and Tyrosine Kinase Inhibitors. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1079228
Modern Language Association (MLA)
Yoshimoto, Mitsuyoshi…[et al.]. Theragnostic Imaging Using Radiolabeled Antibodies and Tyrosine Kinase Inhibitors. The Scientific World Journal No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1079228
American Medical Association (AMA)
Yoshimoto, Mitsuyoshi& Kurihara, Hiroaki& Fujii, Hirofumi. Theragnostic Imaging Using Radiolabeled Antibodies and Tyrosine Kinase Inhibitors. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1079228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1079228