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Application of Vibrational Spectroscopy Supported by Theoretical Calculations in Identification of Amorphous and Crystalline Forms of Cefuroxime Axetil
Joint Authors
Cielecka-Piontek, J.
Lewandowska, K.
Zalewski, P.
Oszczapowicz, I.
Talaczyńska, Alicja
Podborska, Agnieszka
Sikora, Adam
Kozak, Maciej
Jelińska, Anna
Garbacki, Piotr
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
FT-IR and Raman scattering spectra of cefuroxime axetil were proposed for identification studies of its crystalline and amorphous forms.
An analysis of experimental spectra was supported by quantum-chemical calculations performed with the use of B3LYP functional and 6-31G(d,p) as a basis set.
The geometric structure of a cefuroxime axetil molecule, HOMO and LUMO orbitals, and molecular electrostatic potential were also determined by using DFT (density functional theory).
The benefits of applying FT-IR and Raman scattering spectroscopy for characterization of drug subjected to degradation were discussed.
American Psychological Association (APA)
Talaczyńska, Alicja& Lewandowska, K.& Jelińska, Anna& Garbacki, Piotr& Podborska, Agnieszka& Zalewski, P.…[et al.]. 2015. Application of Vibrational Spectroscopy Supported by Theoretical Calculations in Identification of Amorphous and Crystalline Forms of Cefuroxime Axetil. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1079286
Modern Language Association (MLA)
Talaczyńska, Alicja…[et al.]. Application of Vibrational Spectroscopy Supported by Theoretical Calculations in Identification of Amorphous and Crystalline Forms of Cefuroxime Axetil. The Scientific World Journal No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1079286
American Medical Association (AMA)
Talaczyńska, Alicja& Lewandowska, K.& Jelińska, Anna& Garbacki, Piotr& Podborska, Agnieszka& Zalewski, P.…[et al.]. Application of Vibrational Spectroscopy Supported by Theoretical Calculations in Identification of Amorphous and Crystalline Forms of Cefuroxime Axetil. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1079286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1079286