The ameliorative effect of green tea, garlic and vitamin C on arsenic toxicity in male mice : biochemical and histological forensic perspectives
Other Title(s)
التأثير الإيجابي للشاي الأخضر و الثوم و فيتامين ج على سمية الزرنيخ لدى ذكور الفئران : التغيرات البيوكيميائية و النسيجية من منظور جنائي
Joint Authors
al-Harbi, Muhammad Salim
Amir, Sayyid Amin Muhammad
al-Zahrani, Yusuf A. A.
Source
Arab Journal of Forensic Sciences and Forensic Medicine
Issue
Vol. 1, Issue 9 (30 Jun. 2019), pp.1146-1157, 12 p.
Publisher
Naif Arab University for Security Sciences Arab Society for Forensic Sciences and Forensic Medicine
Publication Date
2019-06-30
Country of Publication
Saudi Arabia
No. of Pages
12
Main Subjects
Abstract EN
Arsenic is a heavy metal with toxic effects on human health and is widely found in the environment.
It is used in suicides and, hence, acquires forensic impact.
Sixty adult male albino mice weighing 30-40 g were subjected to a sub-lethal dose of sodium arsenate (40 mg/kg body weight) to investigate hematological, biochemical and histopathological alterations in liver and kidney.
The mice were also co-treated with green tea, garlic and vitamin C to reveal the protective role of these herbal and synthetic antioxidants.
Arsenic induced significant declines in all blood parameters, while green tea, garlic and vitamin C ameliorated these affected hematological parameters.
Alanine transaminase (ALT) and aspartate transaminase (AST) were significantly increased in the sodium arsenate treated group, while green tea, garlic and vitamin C ameliorated these increases in enzyme levels.
Creatinine and urea were significantly increased in arsenic treated mice.
These renal parameters become normal in mice co-treated with green tea, garlic and vitamin C.
Arsenate-treated mice showed venous congestion, sinusoidal dilatation, mononuclear cell infiltration and periportal fibrosis in liver sections.
Kidney samples from the same group revealed interstitial hemorrhages, mononuclear cell infiltration, glomerulonephritis and proximal tubular necrosis.
Hepato-renal injuries were greatly reduced, particularly in animals that received both green tea and garlic.
The herbs used have a potential for ameliorating and protecting against the hepato-renal toxicity caused by arsenic and need further studies.
This study revealed the possibility of using liver and kidney as indicators to ascertain arsenic poisoning in forensic caseworks.
American Psychological Association (APA)
Amir, Sayyid Amin Muhammad& al-Zahrani, Yusuf A. A.& al-Harbi, Muhammad Salim. 2019. The ameliorative effect of green tea, garlic and vitamin C on arsenic toxicity in male mice : biochemical and histological forensic perspectives. Arab Journal of Forensic Sciences and Forensic Medicine،Vol. 1, no. 9, pp.1146-1157.
https://search.emarefa.net/detail/BIM-1086261
Modern Language Association (MLA)
al-Harbi, Muhammad Salim…[et al.]. The ameliorative effect of green tea, garlic and vitamin C on arsenic toxicity in male mice : biochemical and histological forensic perspectives. Arab Journal of Forensic Sciences and Forensic Medicine Vol. 1, no. 9 (2019), pp.1146-1157.
https://search.emarefa.net/detail/BIM-1086261
American Medical Association (AMA)
Amir, Sayyid Amin Muhammad& al-Zahrani, Yusuf A. A.& al-Harbi, Muhammad Salim. The ameliorative effect of green tea, garlic and vitamin C on arsenic toxicity in male mice : biochemical and histological forensic perspectives. Arab Journal of Forensic Sciences and Forensic Medicine. 2019. Vol. 1, no. 9, pp.1146-1157.
https://search.emarefa.net/detail/BIM-1086261
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-1086261