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Evaluation of protective activity of curcumin in reducing methotrexate induced liver cells injury : an experimental study on Iraqi white domestic rabbits
Other Title(s)
تقييم النشاط الوقائي لمادة الكركم في الحد من إصابة خلايا الكبد نتيجة تناول دواء الميثوتريكسيت : دراسة تجريبية على الأرانب العراقية البيضاء
Joint Authors
al-Jabburi, Husayn Abbadi
Abbadi, Ali Husayn
al-Sudani, Isra Mahdi
Source
Journal of Babylon University : Journal of Applied and Pure Sciences
Issue
Vol. 26, Issue 5 (31 May. 2018), pp.145-157, 13 p.
Publisher
Publication Date
2018-05-31
Country of Publication
Iraq
No. of Pages
13
Main Subjects
Abstract EN
Background: Hepatotoxicity is a common problem in medical practice, most of the commonly used drugs are potentially hepatotoxic.
Although Methotrexate is a hepa- toxic drug, it is widely used in the treatment of many cancerous and non-cancerous conditions because of its cytotoxic and immunosuppressant activity.
Curcumin con- tains a variety of natural substances with antioxidant properties, it is widely used in folk medicine.Antioxidant activity of Curcumin can reduce liver cell injury induced by Methotrexate administration.
Objective: The research aims to study the methotrexate hepatoxicity on rabbits, and the hepatoprotective activity of Curcumin.
Materials and Methods: Thirty white domestic rabbits were bought from animal market and grouped randomly into three groups; control group received intraperitoneal normal saline, methotrexate group received 6.5 mg/Kgm body weight intraperitoneal methotrexate, and curcumin group received oral Curcumin in addition to intraperitoneal methotrexate.
Results: The study showed abnormal liver function tests, INR, liver tissues oxida- tive markers, and liver cell injury on histopathology in Methotrexate group, and normal findings in Curcumin groups.
Conclusion: It is concluded that the Methotrexate is a hepatotoxic drug.
The results also shoe that the concomitant administration of Curcumin reduced hepatotoxicity.
Recommendation: It is recommended to use of Curcumin in clinical practice as a food supplement to patient receiving methotrexate to reduce hepatotoxicity.
American Psychological Association (APA)
al-Jabburi, Husayn Abbadi& Abbadi, Ali Husayn& al-Sudani, Isra Mahdi. 2018. Evaluation of protective activity of curcumin in reducing methotrexate induced liver cells injury : an experimental study on Iraqi white domestic rabbits. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 26, no. 5, pp.145-157.
https://search.emarefa.net/detail/BIM-1093466
Modern Language Association (MLA)
al-Jabburi, Husayn Abbadi…[et al.]. Evaluation of protective activity of curcumin in reducing methotrexate induced liver cells injury : an experimental study on Iraqi white domestic rabbits. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 26, no. 5 (2018), pp.145-157.
https://search.emarefa.net/detail/BIM-1093466
American Medical Association (AMA)
al-Jabburi, Husayn Abbadi& Abbadi, Ali Husayn& al-Sudani, Isra Mahdi. Evaluation of protective activity of curcumin in reducing methotrexate induced liver cells injury : an experimental study on Iraqi white domestic rabbits. Journal of Babylon University : Journal of Applied and Pure Sciences. 2018. Vol. 26, no. 5, pp.145-157.
https://search.emarefa.net/detail/BIM-1093466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 156-157
Record ID
BIM-1093466