Histological effect of ursolic acid, hyperinsulinemia and Vitamin B complex on sciatic nerve repair and lipid profile of alloxan induced diabetic rabbits
Joint Authors
Khudayr, Abd al-Razzaq N.
Shaba, Shayma Husayn
Source
Journal of Babylon University : Journal of Applied and Pure Sciences
Issue
Vol. 26, Issue 5 (31 May. 2018), pp.193-203, 11 p.
Publisher
Publication Date
2018-05-31
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Abstract EN
This study aimed to evaluate the effects of ursolic acid, hyperinsulinemia and vitamin B complex on sciatic nerve repair in diabetes mellitus male rabbits, determination of their effects on lipid profile and histological structures of the sciatic nerve.
The results of our study showed that alloxan induced diabetes caused a significant increase (p<0.05) in serum cholesterol and triglyceride while treatment of extracted and standard ursolic acid, hyperinsulinemia and vitamin B complex caused a significant decrease (p<0.05) in serum cholesterol and triglyceride.
There are significantly decreased (p<0.05) in serum high density lipoprotein (HDL) and significantly increase (p<0.05) in serum low density lipoprotein (LDL) is found in induced diabetic and hyperinsulinemia groups while there is a significant increase (p<0.05) of HDL in all treated groups except hyperinsulinemic group, on the other hand, there is a significant decrease (p<0.05) in LDL, especially in extracting ursolic acid group (p<0.05).
Histological sections of sciatic nerve confirmed there is a degeneration of nerve fibers appears as areas of cloudy swelling and fatty de- generation of the nerve fibers due to nerve crush.
There are various improvement changes due to the different treatment type.
American Psychological Association (APA)
Khudayr, Abd al-Razzaq N.& Shaba, Shayma Husayn. 2018. Histological effect of ursolic acid, hyperinsulinemia and Vitamin B complex on sciatic nerve repair and lipid profile of alloxan induced diabetic rabbits. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 26, no. 5, pp.193-203.
https://search.emarefa.net/detail/BIM-1093474
Modern Language Association (MLA)
Khudayr, Abd al-Razzaq N.& Shaba, Shayma Husayn. Histological effect of ursolic acid, hyperinsulinemia and Vitamin B complex on sciatic nerve repair and lipid profile of alloxan induced diabetic rabbits. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 26, no. 5 (2018), pp.193-203.
https://search.emarefa.net/detail/BIM-1093474
American Medical Association (AMA)
Khudayr, Abd al-Razzaq N.& Shaba, Shayma Husayn. Histological effect of ursolic acid, hyperinsulinemia and Vitamin B complex on sciatic nerve repair and lipid profile of alloxan induced diabetic rabbits. Journal of Babylon University : Journal of Applied and Pure Sciences. 2018. Vol. 26, no. 5, pp.193-203.
https://search.emarefa.net/detail/BIM-1093474
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 200-203
Record ID
BIM-1093474