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Evaluated the up-regulation in gene expression of hepatic insulin gene and hepatic insulin receptor gene in type 1 diabetic rats treated with cuscuta chinesis lam.
Joint Authors
al-Husayni, Ibtihal Muizz Abd al-Mahdi
al-Sultani, Fadiyah Hasan
al-Sadi, Ali Hasan
Source
Journal of Babylon University : Journal of Applied and Pure Sciences
Issue
Vol. 26, Issue 4 (30 Apr. 2018), pp.75-93, 19 p.
Publisher
Publication Date
2018-04-30
Country of Publication
Iraq
No. of Pages
19
Main Subjects
Abstract EN
diabetic disease and investigate the molecular and histological mechanism of its action .many parameters was investigated , Fasting blood glucose (FBG), Fasting serum insulin,Hepatic Insulin Gene Expression, pancreas Insulin Gene Expression ,Hepatic Insulin Receptors Gene expression and histological sections of pancrease and liver.54 Rattus rattus male rats weighting(180 -200g) were divided into 3 groups: A normal control daily administrated with Dw, B Diabetic control daily administrated with Dw and C diabetic group daily administrated with 400 mg/Kg body weight of C.
chinesis Lam.
methanolic extract, each group consisted of 18 rats and further divided into (3) sub- groups 1 ,2 and 3.
According to the period of administration 30, 60 and 90 days respectively.
The results showing the daily administration of 400 mg/Kg body weight of C.
chinesis Lam.
methanolic extract for 60 day causing significance decrease in FBG and In the other hand each of fasting serum insulin, hepatic Insulin gene expression,pancreas Insulin gene expression and hepatic Insulin receptor gene expression was increased in group C in compare to B group and return all studied parameters involving pancrease and liver texture to the normal state ,which were statically morphologically not appeared any significant difference from A group .this study concluded that the daily administration type 1 diabetic rats with 400 mg/Kg body weight of C.
chinesis Lam.
extract for 60 day was return fasting serum insulin and FBG to normal value by upregulated the gene expression of hepatic INS Gene ,INSR gene , pancreas INS Gene ,regenerate pancreatic beta- cell and returnthe texture of both liver and pancrease to the normal state
American Psychological Association (APA)
al-Sultani, Fadiyah Hasan& al-Sadi, Ali Hasan& al-Husayni, Ibtihal Muizz Abd al-Mahdi. 2018. Evaluated the up-regulation in gene expression of hepatic insulin gene and hepatic insulin receptor gene in type 1 diabetic rats treated with cuscuta chinesis lam.. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 26, no. 4, pp.75-93.
https://search.emarefa.net/detail/BIM-1093576
Modern Language Association (MLA)
al-Sultani, Fadiyah Hasan…[et al.]. Evaluated the up-regulation in gene expression of hepatic insulin gene and hepatic insulin receptor gene in type 1 diabetic rats treated with cuscuta chinesis lam.. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 26, no. 4 (2018), pp.75-93.
https://search.emarefa.net/detail/BIM-1093576
American Medical Association (AMA)
al-Sultani, Fadiyah Hasan& al-Sadi, Ali Hasan& al-Husayni, Ibtihal Muizz Abd al-Mahdi. Evaluated the up-regulation in gene expression of hepatic insulin gene and hepatic insulin receptor gene in type 1 diabetic rats treated with cuscuta chinesis lam.. Journal of Babylon University : Journal of Applied and Pure Sciences. 2018. Vol. 26, no. 4, pp.75-93.
https://search.emarefa.net/detail/BIM-1093576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 91-93
Record ID
BIM-1093576