Antimicrobial Efficacy and Cell Adhesion Inhibition of In Situ Synthesized ZnO NanoparticlesPolyvinyl Alcohol Nanofibrous Membranes
Joint Authors
Li, Jian
Zhang, Qun
Xu, Minjing
Wu, Changzhu
Li, Ping
Source
Advances in Condensed Matter Physics
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nanoparticle metal oxides are emerging as a new class of important materials in medical, agricultural, and industrial applications.
In this context, free zinc oxide (ZnO) nanoparticles (NPs) have been increasingly shown with broad antimicrobial activities.
However, biological properties of immobilized ZnO NPs on matrixes like nanofibrous membranes are still limited.
In this study, in situ synthesized ZnO NPs/polyvinyl alcohol (PVA) nanofibrous membranes were fabricated by electrospinning with different zinc acetate concentrations.
Characterization results indicated that, with 5 mM zinc acetate, uniform size ZnO NPs (~40 nm) were formed and evenly distributed on the membrane surface.
The surfaces became more hydrophobic with higher concentration of zinc acetate.
ZnO NPs/PVA nanofibrous membranes showed a broad spectrum of antimicrobial activities and cell adhesion inhibiting effects against four microorganisms including Gram-positive Staphylococcus aureus, Gram-negative Escherichia coli, fungi Candida albicans, and spores of Aspergillus niger.
Our data revealed that the major antimicrobial mechanism could be attributed to cell membrane damage and cellular internalization of ZnO NPs, while the hydrophobic surface of the membrane primarily contributed to the cell adhesion inhibition.
This study suggests that ZnO NPs/PVA nanofibrous membranes could potentially be used as an effective antimicrobial agent to maintain agricultural and food safety.
American Psychological Association (APA)
Li, Jian& Zhang, Qun& Xu, Minjing& Wu, Changzhu& Li, Ping. 2016. Antimicrobial Efficacy and Cell Adhesion Inhibition of In Situ Synthesized ZnO NanoparticlesPolyvinyl Alcohol Nanofibrous Membranes. Advances in Condensed Matter Physics،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1094943
Modern Language Association (MLA)
Li, Jian…[et al.]. Antimicrobial Efficacy and Cell Adhesion Inhibition of In Situ Synthesized ZnO NanoparticlesPolyvinyl Alcohol Nanofibrous Membranes. Advances in Condensed Matter Physics No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1094943
American Medical Association (AMA)
Li, Jian& Zhang, Qun& Xu, Minjing& Wu, Changzhu& Li, Ping. Antimicrobial Efficacy and Cell Adhesion Inhibition of In Situ Synthesized ZnO NanoparticlesPolyvinyl Alcohol Nanofibrous Membranes. Advances in Condensed Matter Physics. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1094943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1094943