PECAM-1 Leu125Val (rs688) Polymorphism and Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus
Joint Authors
Petrovič, Daniel
Završnik, Matej
Kariž, Stojan
Makuc, Jana
Šeruga, Maja
Cilenšek, Ines
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
Platelet endothelial cell adhesion molecule-1 (PECAM-1) plays a key role in the transendothelial migration of circulating leukocytes during inflammation and in the maintenance of vascular endothelial integrity.
We hypothesized that genetic variation in PECAM-1 gene could be associated with diabetic nephropathy (DN) and with the level of soluble PECAM-1 in Caucasians with type 2 diabetes mellitus (T2DM).
Design and Methods.
We analyzed the rs688 single nucleotide polymorphism of PECAM-1 gene C373G (Leu125Val) at exon 3, which encodes the first extracellular Ig-like domain that mediates the homophilic binding of PECAM-1, in 276 T2DM subjects with documented DN (cases) and 375 T2DM subjects without DN (controls), using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) strategy.
Level of plasma soluble PECAM-1 (sPECAM-1) was measured by ELISA in a subpopulation of 120 diabetics with DN.
Results.
We found no association between the Leu125Val polymorphism and DN in subjects with T2DM.
Likewise, the Leu125Val polymorphism was not associated with serum sPECAM-1 levels in a subpopulation of 120 diabetics with DN.
Conclusion.
The Leu125Val polymorphism of PECAM-1 and the level of sPECAM-1 are not associated with DN in T2DM subjects of Slovenian origin.
American Psychological Association (APA)
Završnik, Matej& Kariž, Stojan& Makuc, Jana& Šeruga, Maja& Cilenšek, Ines& Petrovič, Daniel. 2016. PECAM-1 Leu125Val (rs688) Polymorphism and Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus. Analytical Cellular Pathology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1094960
Modern Language Association (MLA)
Završnik, Matej…[et al.]. PECAM-1 Leu125Val (rs688) Polymorphism and Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus. Analytical Cellular Pathology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1094960
American Medical Association (AMA)
Završnik, Matej& Kariž, Stojan& Makuc, Jana& Šeruga, Maja& Cilenšek, Ines& Petrovič, Daniel. PECAM-1 Leu125Val (rs688) Polymorphism and Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus. Analytical Cellular Pathology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1094960
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1094960