Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy
Joint Authors
Cavalcanti, Ernesta
Barchiesi, Vittoria
Cerasuolo, Dionigio
Di Paola, Flaviano
Cantile, Monica
Cecere, Sabrina Chiara
Pignata, Sandro
Di Maio, Massimo
Perrone, Francesco
Costanzo, Raffaele
Morabito, Alessandro
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
Serum cystatin C seems to be an accurate marker of glomerular filtration rate (GFR) compared to serum creatinine.
The aim of this work was to explore the possibility of using serum cystatin C instead of serum creatinine to early predict renal failure in cancer patients who received platinum based chemotherapy.
Design and Methods.
Serum creatinine, serum cystatin C concentrations, and GFR were determined simultaneously in 52 cancer patients received carboplatin-based or cisplatin-based chemotherapy.
Serum creatinine was assayed on Cobas C6000-Roche, serum cystatin C assay was performed on AIA 360-Tosoh, and GFR was determined in all patients, before the first cycle of chemotherapy and before the subsequent administrations.
Results.
In the overall series, for the prediction of a fall of GFR < 80 mL/min/1.73 m2, the AUC of the ROC curve for cystatin C was 0,667 and the best threshold was 1.135 mg/L (sensitivity 90.5%, specificity 61.1%).
For a GFR fall < 60 mL/min/1.73 m2, the AUC of ROC curve for cystatin C was 74.3% and the best threshold was 1.415 mg/L (sensitivity 66.7%, specificity 73.2%).
Conclusions.
Baseline cystatin C values were not able to predict renal failure during subsequent treatment.
In conclusion, serum cystatin C is not a reliable early marker to efficiently predict renal failure in patients receiving chemotherapy.
American Psychological Association (APA)
Cavalcanti, Ernesta& Barchiesi, Vittoria& Cerasuolo, Dionigio& Di Paola, Flaviano& Cantile, Monica& Cecere, Sabrina Chiara…[et al.]. 2016. Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy. Analytical Cellular Pathology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1094964
Modern Language Association (MLA)
Cavalcanti, Ernesta…[et al.]. Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy. Analytical Cellular Pathology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1094964
American Medical Association (AMA)
Cavalcanti, Ernesta& Barchiesi, Vittoria& Cerasuolo, Dionigio& Di Paola, Flaviano& Cantile, Monica& Cecere, Sabrina Chiara…[et al.]. Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy. Analytical Cellular Pathology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1094964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1094964