VEGF +936 CT Genetic Polymorphism in Patients with Cervical Dysplasia

Abstract EN

Aim.

The present study aims to analyze the potential role of VEGF +936 C/T polymorphism in cervical intraepithelial neoplasia.

Material and Method.

One hundred and eighty-six patients were included in the study: 75 cases (patients diagnosed with CIN) and 111 controls (negative for both HPV testing and cytology).

For each patient a single visit was scheduled when colposcopy was performed.

From cervical specimen, cytology and HPV testing were performed and from peripheral blood VEGF +936 genotyping was determined.

For statistical analysis purposes OR and chi-square were used at a level of significance of <0.05.

Results.

No link has been found in the detection of CT genotype in cases versus controls, OR = 0.8295, [0.42, 1.62].

An inverse correlation has been found between T allele and HSIL, OR = 0.2121, [0.0473, 0.9517], p=0.0866.

Conclusion.

No link has been found between VEGF +936 C/T and cervical intraepithelial neoplasia.