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Predictive and Prognostic Value of sPRR in Patients with Primary Epithelial Ovarian Cancer
Joint Authors
Dragun, Duska
Kreienbring, Katrin
Franz, Annika
Richter, Rolf
Heidecke, Harald
Dechend, Ralf
Braicu, Elena Iona
Sehouli, Jalid
Müller, Dominik N.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
The purpose of the present study was to analyze the predictive and prognostic role of soluble (pro)renin receptor (sPRR) as a biomarker for clinicopathological outcome in patients with primary epithelial ovarian cancer (EOC).
As part of the renin-angiotensin system (RAS) whose activity is known to increase in ovarian cancer patients, the relation of sPRR and ovarian cancer should be further investigated.
Patients and Methods.
In this study 197 patients with primary EOC in our institution from 2000 to 2011 were included.
sPRR was determined by enzyme-linked immunosorbent assay (ELISA) in preoperative taken blood sera.
Associations with clinicopathological outcome were analyzed and serum levels of sPRR in patients have been compared to those in healthy specimen.
Kaplan-Meier and logistic/Cox regression assessed the impact of the markers on progression-free survival (PFS) and overall survival (OS).
Results.
There have been no correlations proved of sPRR levels with neither clinicopathological factors nor prognostic data.
Also the distribution of sPRR in patients and controls was normal.
Conclusion.
sPRR seems to have no predictive, prognostic, or diagnostic value in EOC.
As several factors of the RAS which might indicate cancer events have been shown, sPRR seems not to be affected.
American Psychological Association (APA)
Kreienbring, Katrin& Franz, Annika& Richter, Rolf& Dragun, Duska& Heidecke, Harald& Dechend, Ralf…[et al.]. 2016. Predictive and Prognostic Value of sPRR in Patients with Primary Epithelial Ovarian Cancer. Analytical Cellular Pathology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1094969
Modern Language Association (MLA)
Kreienbring, Katrin…[et al.]. Predictive and Prognostic Value of sPRR in Patients with Primary Epithelial Ovarian Cancer. Analytical Cellular Pathology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1094969
American Medical Association (AMA)
Kreienbring, Katrin& Franz, Annika& Richter, Rolf& Dragun, Duska& Heidecke, Harald& Dechend, Ralf…[et al.]. Predictive and Prognostic Value of sPRR in Patients with Primary Epithelial Ovarian Cancer. Analytical Cellular Pathology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1094969
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1094969