Transcription Factor HBP1 Enhances Radiosensitivity by Inducing Apoptosis in Prostate Cancer Cell Lines
Joint Authors
Chen, Yicheng
Wang, Yueping
Yu, Yanlan
Xu, Liwei
Zhang, Youyun
Yu, Shicheng
Li, Gonghui
Zhang, Zhigeng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Radiotherapy for prostate cancer has been gradually carried out in recent years; however, acquired radioresistance often occurred in some patients after radiotherapy.
HBP1 (HMG-box transcription factor 1) is a transcriptional inhibitor which could inhibit the expression of dozens of oncogenes.
In our previous study, we showed that the expression level of HBP1 was closely related to prostate cancer metastasis and prognosis, but the relationship between HBP1 and radioresistance for prostate cancer is largely unknown.
In this study, the clinical data of patients with prostate cancer was compared, and the positive correlation was revealed between prostate cancer brachytherapy efficacy and the expression level of HBP1 gene.
Through research on prostate cancer cells in vitro, we found that HBP1 expression levels were negatively correlated with oncogene expression levels.
Furthermore, HBP1 overexpression could sensitize prostate cancer cells to radiation and increase apoptosis in prostate cancer cells.
In addition, animal model was employed to analyze the relationship between HBP1 gene and prostate cancer radiosensitivity in vivo; the result showed that knockdown of HBP1 gene could decrease the sensitivity to radiation of xenograft.
These studies identified a specific molecular mechanism underlying prostate cancer radiosensitivity, which suggested HBP1 as a novel target in prostate cancer radiotherapy.
American Psychological Association (APA)
Chen, Yicheng& Wang, Yueping& Yu, Yanlan& Xu, Liwei& Zhang, Youyun& Yu, Shicheng…[et al.]. 2016. Transcription Factor HBP1 Enhances Radiosensitivity by Inducing Apoptosis in Prostate Cancer Cell Lines. Analytical Cellular Pathology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1094971
Modern Language Association (MLA)
Chen, Yicheng…[et al.]. Transcription Factor HBP1 Enhances Radiosensitivity by Inducing Apoptosis in Prostate Cancer Cell Lines. Analytical Cellular Pathology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1094971
American Medical Association (AMA)
Chen, Yicheng& Wang, Yueping& Yu, Yanlan& Xu, Liwei& Zhang, Youyun& Yu, Shicheng…[et al.]. Transcription Factor HBP1 Enhances Radiosensitivity by Inducing Apoptosis in Prostate Cancer Cell Lines. Analytical Cellular Pathology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1094971
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1094971