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Hepatoma-Targeted Radionuclide Immune Albumin Nanospheres: 131I-antiAFPMcAb-GCV-BSA-NPs
Joint Authors
Zhang, Dongsheng
Lin, Mei
Huang, Junxing
Shi, Yujuan
Xiao, Yanhong
Guo, Ting
Yu, Hong
Jiang, Xingmao
Zhang, Jia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
An effective strategy has been developed for synthesis of radionuclide immune albumin nanospheres (131I-antiAFPMcAb-GCV-BSA-NPs).
In vitro as well as in vivo targeting of 131I-antiAFPMcAb-GCV-BSA-NPs to AFP-positive hepatoma was examined.
In cultured HepG2 cells, the uptake and retention rates of 131I-antiAFPMcAb-GCV-BSA-NPs were remarkably higher than those of 131I alone.
As well, the uptake rate and retention ratios of 131I-antiAFPMcAb-GCV-BSA-NPs in AFP-positive HepG2 cells were also significantly higher than those in AFP-negative HEK293 cells.
Compared to 131I alone, 131I-antiAFPMcAb-GCV-BSA-NPs were much more easily taken in and retained by hepatoma tissue, with a much higher T/NT.
Due to good drug-loading, high encapsulation ratio, and highly selective affinity for AFP-positive tumors, the 131I-antiAFPMcAb-GCV-BSA-NPs are promising for further effective radiation-gene therapy of hepatoma.
American Psychological Association (APA)
Lin, Mei& Huang, Junxing& Zhang, Dongsheng& Jiang, Xingmao& Zhang, Jia& Yu, Hong…[et al.]. 2016. Hepatoma-Targeted Radionuclide Immune Albumin Nanospheres: 131I-antiAFPMcAb-GCV-BSA-NPs. Analytical Cellular Pathology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1094977
Modern Language Association (MLA)
Lin, Mei…[et al.]. Hepatoma-Targeted Radionuclide Immune Albumin Nanospheres: 131I-antiAFPMcAb-GCV-BSA-NPs. Analytical Cellular Pathology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1094977
American Medical Association (AMA)
Lin, Mei& Huang, Junxing& Zhang, Dongsheng& Jiang, Xingmao& Zhang, Jia& Yu, Hong…[et al.]. Hepatoma-Targeted Radionuclide Immune Albumin Nanospheres: 131I-antiAFPMcAb-GCV-BSA-NPs. Analytical Cellular Pathology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1094977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1094977