Prooxidant-Antioxidant Balance in Patients with Systemic Lupus Erythematosus and Its Relationship with Clinical and Laboratory Findings
Joint Authors
Sandoughi, Mahnaz
Salimi, Saeedeh
Zakeri, Zahra
Jafari, Seyyed Mehdi
Nakhaee, Alireza
Kalani, Hamed
Farajian-Mashhadi, Farzaneh
Tavallaie, Shima
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim.
This study was aimed at evaluating prooxidant-antioxidant balance (PAB) in patients with systemic lupus erythematosus (SLE) and its relationship with laboratory findings and clinical manifestations.
Methods.
In this case-control study, 60 patients with SLE and 60 healthy individuals were enrolled.
The blood samples were collected and their sera were separated.
Subsequently, the prooxidant-antioxidant balance value was evaluated using PAB assay for each sample.
Results.
The mean of PAB values in SLE patients was significantly higher than healthy controls ( 147.3 ± 42 versus 84.8 ± 32.2 HK, P < 0.0001 ).
Furthermore, in SLE patients, there was a positive significant correlation between the PAB and erythrocyte sedimentation rate (ESR) ( r = 0.492 , P < 0.001 ).
In addition, the PAB values in patients with alopecia, discoid rash, oral ulcers, arthritis, and nephritis were significantly higher than those without these manifestations.
Conclusion.
The findings of current study showed that the mean of PAB was significantly higher in SLE patients and PAB was correlated with ESR.
Moreover increased PAB was found in SLE patients with alopecia, discoid rash, oral ulcers, arthritis, and nephritis.
These findings suggest that the measurement of PAB may be useful to show oxidative stress condition in SLE patients.
American Psychological Association (APA)
Jafari, Seyyed Mehdi& Salimi, Saeedeh& Nakhaee, Alireza& Kalani, Hamed& Tavallaie, Shima& Farajian-Mashhadi, Farzaneh…[et al.]. 2016. Prooxidant-Antioxidant Balance in Patients with Systemic Lupus Erythematosus and Its Relationship with Clinical and Laboratory Findings. Autoimmune Diseases،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1094981
Modern Language Association (MLA)
Jafari, Seyyed Mehdi…[et al.]. Prooxidant-Antioxidant Balance in Patients with Systemic Lupus Erythematosus and Its Relationship with Clinical and Laboratory Findings. Autoimmune Diseases No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1094981
American Medical Association (AMA)
Jafari, Seyyed Mehdi& Salimi, Saeedeh& Nakhaee, Alireza& Kalani, Hamed& Tavallaie, Shima& Farajian-Mashhadi, Farzaneh…[et al.]. Prooxidant-Antioxidant Balance in Patients with Systemic Lupus Erythematosus and Its Relationship with Clinical and Laboratory Findings. Autoimmune Diseases. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1094981
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1094981