Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease
Joint Authors
Almeida, Lucas Malta
Gandolfi, Lenora
Pratesi, Riccardo
Uenishi, Rosa Harumi
Almeida, Fernanda Coutinho de
Selleski, Nicole
Nóbrega, Yanna Karla de Medeiros
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Celiac disease (CD) is a genetically determined immune-mediated disorder in which gluten immunogenic peptides are presented to CD4 T cells by HLA-DQ2.5, DQ8, DQ2.2, and their combinations.
Our aim is to establish a risk gradient for celiac disease based on HLA-DQ profile in a brazilian representative population and the relevance of DQ2.2 in celiac disease development.
Materials and Methods.
237 celiac patients and 237 controls (both groups with 164 females and 73 males) were included.
All samples were tested for the presence of predisposing HLA-DQ alleles using the PCR-SSP method.
Results were considered significant when p<0.05.
Disease risk was expressed as 1 : N for each HLA-DQ category described at this study.
Results.
DQ2.5 and/or DQ8 were detected in 224 celiac patients (94.5%) and 84 controls (35.4%).
Eight celiac patients (3.4%) and 38 controls (16%) disclosed only DQ2.2.
Even though DQ2.2 (β2/β2 or β2/x) showed a low CD risk of 1 : 251 and 1 : 550, respectively, the genotype DQ2.5/DQ2.2 (β2/β2) showed high CD risk of 1 : 10 (p<0.0001).
The disease risk gradient ranged from 1 : 3014 to 1 : 7.
Conclusion.
Our study allowed the determination of a risk gradient for celiac disease development in at-risk population, showing that DQ2.2 variant was relevant when associated with DQ2.5.
American Psychological Association (APA)
Almeida, Lucas Malta& Gandolfi, Lenora& Pratesi, Riccardo& Uenishi, Rosa Harumi& Almeida, Fernanda Coutinho de& Selleski, Nicole…[et al.]. 2016. Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease. Autoimmune Diseases،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1094982
Modern Language Association (MLA)
Almeida, Lucas Malta…[et al.]. Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease. Autoimmune Diseases No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1094982
American Medical Association (AMA)
Almeida, Lucas Malta& Gandolfi, Lenora& Pratesi, Riccardo& Uenishi, Rosa Harumi& Almeida, Fernanda Coutinho de& Selleski, Nicole…[et al.]. Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease. Autoimmune Diseases. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1094982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1094982