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Haploidentical Transplantation in Children with Acute Leukemia: The Unresolved Issues
Joint Authors
Chakrabarti, Suparno
Jaiswal, Sarita Rani
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Allogeneic hematopoietic stem cell transplantation (HSCT) remains a curative option for children with high risk and advanced acute leukemia.
Yet availability of matched family donor limits its use and although matched unrelated donor or mismatched umbilical cord blood (UCB) are viable options, they fail to meet the global need.
Haploidentical family donor is almost universally available and is emerging as the alternate donor of choice in adult patients.
However, the same is not true in the case of children.
The studies of haploidentical HSCT in children are largely limited to T cell depleted grafts with not so encouraging results in advanced leukemia.
At the same time, emerging data from UCBT are challenging the existing paradigm of less stringent HLA match requirements as perceived in the past.
The use of posttransplantation cyclophosphamide (PTCY) has yielded encouraging results in adults, but data in children is sorely lacking.
Our experience of using PTCY based haploidentical HSCT in children shows inadequacy of this approach in younger children compared to excellent outcome in older children.
In this context, we discuss the current status of haploidentical HSCT in children with acute leukemia in a global perspective and dwell on its future prospects.
American Psychological Association (APA)
Jaiswal, Sarita Rani& Chakrabarti, Suparno. 2016. Haploidentical Transplantation in Children with Acute Leukemia: The Unresolved Issues. Advances in Hematology،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1095097
Modern Language Association (MLA)
Jaiswal, Sarita Rani& Chakrabarti, Suparno. Haploidentical Transplantation in Children with Acute Leukemia: The Unresolved Issues. Advances in Hematology No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1095097
American Medical Association (AMA)
Jaiswal, Sarita Rani& Chakrabarti, Suparno. Haploidentical Transplantation in Children with Acute Leukemia: The Unresolved Issues. Advances in Hematology. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1095097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1095097