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Influence of Oxidative Stress on Stored Platelets
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Platelet storage and its availability for transfusion are limited to 5-6 days.
Oxidative stress (OS) is one of the causes for reduced efficacy and shelf-life of platelets.
The studies on platelet storage have focused on improving the storage conditions by altering platelet storage solutions, temperature, and materials.
Nevertheless, the role of OS on platelet survival during storage is still unclear.
Hence, this study was conducted to investigate the influence of storage on platelets.
Platelets were stored for 12 days at 22°C.
OS markers such as aggregation, superoxides, reactive oxygen species, glucose, pH, lipid peroxidation, protein oxidation, and antioxidant enzymes were assessed.
OS increased during storage as indicated by increments in aggregation, superoxides, pH, conjugate dienes, and superoxide dismutase and decrements in glucose and catalase.
Thus, platelets could endure OS till 6 days during storage, due to the antioxidant defense system.
An evident increase in OS was observed from day 8 of storage, which can diminish the platelet efficacy.
The present study provides an insight into the gradual changes occurring during platelet storage.
This lays the foundation towards new possibilities of employing various antioxidants as additives in storage solutions.
American Psychological Association (APA)
Manasa, K.& Vani, R.. 2016. Influence of Oxidative Stress on Stored Platelets. Advances in Hematology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1095101
Modern Language Association (MLA)
Manasa, K.& Vani, R.. Influence of Oxidative Stress on Stored Platelets. Advances in Hematology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1095101
American Medical Association (AMA)
Manasa, K.& Vani, R.. Influence of Oxidative Stress on Stored Platelets. Advances in Hematology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1095101
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1095101