Osteogenic Potential of Multipotent Adult Progenitor Cells for Calvaria Bone Regeneration
Joint Authors
Lee, Dong Joon
Park, Yonsil
Ko, Ching-Chang
Hu, Wei-Shou
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Osteogenic cells derived from rat multipotent adult progenitor cells (rMAPCs) were investigated for their potential use in bone regeneration.
rMAPCs are adult stem cells derived from bone marrow that have a high proliferation capacity and the differentiation potential to multiple lineages.
They may also offer immunomodulatory properties favorable for applications for regenerative medicine.
rMAPCs were cultivated as single cells or as 3D aggregates in osteogenic media for up to 38 days, and their differentiation to bone lineage was then assessed by immunostaining of osteocalcin and collagen type I and by mineralization assays.
The capability of rMAPCs in facilitating bone regeneration was evaluated in vivo by the direct implantation of multipotent adult progenitor cell (MAPC) aggregates in rat calvarial defects.
Bone regeneration was examined radiographically, histologically, and histomorphometrically.
Results showed that rMAPCs successfully differentiated into osteogenic lineage by demonstrating mineralized extracellular matrix formation in vitro and induced new bone formation by the effect of rMAPC aggregates in vivo.
These outcomes confirm that rMAPCs have a good osteogenic potential and provide insights into rMAPCs as a novel adult stem cell source for bone regeneration.
American Psychological Association (APA)
Lee, Dong Joon& Park, Yonsil& Hu, Wei-Shou& Ko, Ching-Chang. 2016. Osteogenic Potential of Multipotent Adult Progenitor Cells for Calvaria Bone Regeneration. Advances in Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1095312
Modern Language Association (MLA)
Lee, Dong Joon…[et al.]. Osteogenic Potential of Multipotent Adult Progenitor Cells for Calvaria Bone Regeneration. Advances in Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1095312
American Medical Association (AMA)
Lee, Dong Joon& Park, Yonsil& Hu, Wei-Shou& Ko, Ching-Chang. Osteogenic Potential of Multipotent Adult Progenitor Cells for Calvaria Bone Regeneration. Advances in Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1095312
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1095312