Assessment of Newly Proposed Clinical Criteria to Identify HNF1A MODY in Patients with an Initial Diagnosis of Type 1 or Type 2 Diabetes Mellitus
Joint Authors
Klupa, Tomasz
Matejko, Bartlomiej
Kiec-Wilk, Beata
Grzanka, Malgorzata
Szopa, Magdalena
Malecki, Maciej T.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-28
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
The most common form of maturity-onset diabetes of the young (MODY) is caused by mutations in the hepatocyte nuclear factor 1A (HNF1A) gene.
However, most HNF1A mutation-carriers are initially misdiagnosed with type 1 (T1DM) or type 2 (T2DM) diabetes mellitus; hence, they often receive nonoptimal treatment.
The aim of our study was to test newly proposed clinical criteria for the identification of HNF1A MODY in patients with a diagnosis of T1DM or T2DM.
To achieve this, the following criteria to preselect patients for screening were used: for T1DM: TDIR (total daily insulin requirement) > 0.3 IU of insulin/kg and the percentage of basal insulin > 30% of TDIR; for T2DM: sulphonylurea- (SU-) based oral treatment (monotherapy or combined with Metformin) > 15 years and BMI < 30 kg/m2.
We reviewed the clinical data of 140 patients with T1DM and 524 clinically diagnosed with T2DM.
On the basis of these criteria, we found a HNF1A mutation in 1 out of 2 individuals with a diagnosis of T1DM and 1 out of 11 selected individuals with a diagnosis of T2DM.
We believe that the simplicity of the proposed criteria might prove useful in clinical practice, as an alternative to more time-consuming classical diagnostic techniques.
American Psychological Association (APA)
Grzanka, Malgorzata& Matejko, Bartlomiej& Szopa, Magdalena& Kiec-Wilk, Beata& Malecki, Maciej T.& Klupa, Tomasz. 2016. Assessment of Newly Proposed Clinical Criteria to Identify HNF1A MODY in Patients with an Initial Diagnosis of Type 1 or Type 2 Diabetes Mellitus. Advances in Medicine،Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1095321
Modern Language Association (MLA)
Grzanka, Malgorzata…[et al.]. Assessment of Newly Proposed Clinical Criteria to Identify HNF1A MODY in Patients with an Initial Diagnosis of Type 1 or Type 2 Diabetes Mellitus. Advances in Medicine No. 2016 (2016), pp.1-3.
https://search.emarefa.net/detail/BIM-1095321
American Medical Association (AMA)
Grzanka, Malgorzata& Matejko, Bartlomiej& Szopa, Magdalena& Kiec-Wilk, Beata& Malecki, Maciej T.& Klupa, Tomasz. Assessment of Newly Proposed Clinical Criteria to Identify HNF1A MODY in Patients with an Initial Diagnosis of Type 1 or Type 2 Diabetes Mellitus. Advances in Medicine. 2016. Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1095321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1095321