Topical Colchicine Gel versus Diclofenac Sodium Gel for the Treatment of Actinic Keratoses: A Randomized, Double-Blind Study
Joint Authors
Faghihi, Gita
Iraji, Fariba
Elahipoor, Azam
Behfar, Shadi
Abtahi-Naeini, Bahareh
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Actinic keratoses (AKs), a premalignant skin lesion, are a common lesion in fair skin.
Although destructive treatment remains the gold standard for AKs, medical therapies may be preferable due to the comfort and reliability .This study aims to compare the effects of topical 1% colchicine gel and 3% diclofenac sodium gel in AKs.
Materials and Methods.
In this randomized double-blind study, 70 lesions were selected.
Patients were randomized before receiving either 1% colchicine gel or 3% diclofenac sodium cream twice a day for 6 weeks.
Patients were evaluated in terms of their lesion size, treatment complications, and recurrence at 7, 30, 60, and 120 days after treatment.
Results.
The mean of changes in the size was significant in both groups both before and after treatment (<0.001).
The mean lesion size before treatment and at 30, 60, and 120 days was not different between the two groups ( p > 0.05).
No case of erythema was seen in the colchicine group, while erythema was seen in 22.9% (eight cases) of patients in the diclofenac sodium group ( p = 0.005).
Conclusions.
1% colchicine gel was a safe and effective medication with fewer side effects and lack of recurrence of the lesion.
American Psychological Association (APA)
Faghihi, Gita& Elahipoor, Azam& Iraji, Fariba& Behfar, Shadi& Abtahi-Naeini, Bahareh. 2016. Topical Colchicine Gel versus Diclofenac Sodium Gel for the Treatment of Actinic Keratoses: A Randomized, Double-Blind Study. Advances in Medicine،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1095326
Modern Language Association (MLA)
Faghihi, Gita…[et al.]. Topical Colchicine Gel versus Diclofenac Sodium Gel for the Treatment of Actinic Keratoses: A Randomized, Double-Blind Study. Advances in Medicine No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1095326
American Medical Association (AMA)
Faghihi, Gita& Elahipoor, Azam& Iraji, Fariba& Behfar, Shadi& Abtahi-Naeini, Bahareh. Topical Colchicine Gel versus Diclofenac Sodium Gel for the Treatment of Actinic Keratoses: A Randomized, Double-Blind Study. Advances in Medicine. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1095326
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1095326