Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease
Joint Authors
Paudel, Keshav Raj
Panth, Nisha
Parajuli, Kalpana
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cardiovascular diseases (CVDs) have been the prime cause of mortality worldwide for decades.
However, the underlying mechanism of their pathogenesis is not fully clear yet.
It has been already established that reactive oxygen species (ROS) play a vital role in the progression of CVDs.
ROS are chemically unstable reactive free radicals containing oxygen, normally produced by xanthine oxidase, nicotinamide adenine dinucleotide phosphate oxidase, lipoxygenases, or mitochondria or due to the uncoupling of nitric oxide synthase in vascular cells.
When the equilibrium between production of free radicals and antioxidant capacity of human physiology gets altered due to several pathophysiological conditions, oxidative stress is induced, which in turn leads to tissue injury.
This review focuses on pathways behind the production of ROS, its involvement in various intracellular signaling cascades leading to several cardiovascular disorders (endothelial dysfunction, ischemia-reperfusion, and atherosclerosis), methods for its detection, and therapeutic strategies for treatment of CVDs targeting the sources of ROS.
The information generated by this review aims to provide updated insights into the understanding of the mechanisms behind cardiovascular complications mediated by ROS.
American Psychological Association (APA)
Panth, Nisha& Paudel, Keshav Raj& Parajuli, Kalpana. 2016. Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease. Advances in Medicine،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1095341
Modern Language Association (MLA)
Panth, Nisha…[et al.]. Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease. Advances in Medicine No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1095341
American Medical Association (AMA)
Panth, Nisha& Paudel, Keshav Raj& Parajuli, Kalpana. Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease. Advances in Medicine. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1095341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1095341