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Antifungal Susceptibility Patterns of Candida Species Recovered from Endotracheal Tube in an Intensive Care Unit
Joint Authors
Khodavaisy, Sadegh
Baghdadi, Elham
Rezaie, Sassan
Abolghasem, Sara
Kiasat, Neda
Salehi, Zahra
Sharifynia, Somayeh
Aala, Farzad
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aims.
Biofilms formed by Candida species which associated with drastically enhanced resistance against most antimicrobial agents.
The aim of this study was to identify and determine the antifungal susceptibility pattern of Candida species isolated from endotracheal tubes from ICU patients.
Methods.
One hundred forty ICU patients with tracheal tubes who were intubated and mechanically ventilated were surveyed for endotracheal tube biofilms.
Samples were processed for quantitative microbial culture.
Yeast isolates were identified to the species level based on morphological characteristics and their identity was confirmed by PCR-RFLP.
Antifungal susceptibility testing was determined according to CLSI document (M27-A3).
Results.
Ninety-five strains of Candida were obtained from endotracheal tubes of which C.
albicans ( n = 34 ; 35.7%) was the most frequently isolated species followed by other species which included C.
glabrata ( n = 24 ; 25.2%), C.
parapsilosis ( n = 16 ; 16.8%), C.
tropicalis ( n = 12 ; 12.6%), and C.
krusei ( n = 9 ; 9.4%).
The resulting MIC90 for all Candida species were in increasing order as follows: caspofungin (0.5 μg/mL); amphotericin B (2 μg/mL); voriconazole (8.8 μg/mL); itraconazole (16 μg/mL); and fluconazole (64 μg/mL).
Conclusion.
Candida species recovered from endotracheal tube are the most susceptible to caspofungin.
American Psychological Association (APA)
Baghdadi, Elham& Khodavaisy, Sadegh& Rezaie, Sassan& Abolghasem, Sara& Kiasat, Neda& Salehi, Zahra…[et al.]. 2016. Antifungal Susceptibility Patterns of Candida Species Recovered from Endotracheal Tube in an Intensive Care Unit. Advances in Medicine،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1095343
Modern Language Association (MLA)
Baghdadi, Elham…[et al.]. Antifungal Susceptibility Patterns of Candida Species Recovered from Endotracheal Tube in an Intensive Care Unit. Advances in Medicine No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1095343
American Medical Association (AMA)
Baghdadi, Elham& Khodavaisy, Sadegh& Rezaie, Sassan& Abolghasem, Sara& Kiasat, Neda& Salehi, Zahra…[et al.]. Antifungal Susceptibility Patterns of Candida Species Recovered from Endotracheal Tube in an Intensive Care Unit. Advances in Medicine. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1095343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1095343