Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration
Joint Authors
Albu, Mădălina
Mederle, Narcisa
Marin, Stefania
Marin, Minodora Maria
Danila, Elena
Mederle, Ovidiu
Ghica, Mihaela Violeta
Source
Advances in Materials Science and Engineering
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-22
Country of Publication
Egypt
No. of Pages
5
Abstract EN
Bone regeneration is a serious challenge in orthopedic applications because of bone infections increase, tumor developing, and bone loss due to trauma.
In this context, the aim of our study was to develop innovative biomaterials based on collagen and hydroxyapatite (25, 50, and 75%) which mimic bone composition and prevent or treat infections due to doxycycline content.
The biomaterials were obtained by freeze-drying in spongious forms and were characterized by water uptake capacity and microscopy.
The in vitro release of doxycycline was also determined and established by non-Fickian drug transport mechanism.
Among the studied biomaterials, the most suitable one to easily deliver the drug and mimic bone structure, having compact structure and lower capacity to uptake water, was the one with 75% hydroxyapatite and being cross-linked.
American Psychological Association (APA)
Mederle, Narcisa& Marin, Stefania& Marin, Minodora Maria& Danila, Elena& Mederle, Ovidiu& Albu, Mădălina…[et al.]. 2016. Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration. Advances in Materials Science and Engineering،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1096100
Modern Language Association (MLA)
Mederle, Narcisa…[et al.]. Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration. Advances in Materials Science and Engineering No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1096100
American Medical Association (AMA)
Mederle, Narcisa& Marin, Stefania& Marin, Minodora Maria& Danila, Elena& Mederle, Ovidiu& Albu, Mădălina…[et al.]. Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration. Advances in Materials Science and Engineering. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1096100
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096100