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Development and Physicochemical Characterization of Desonide-Loaded Nanocapsule Suspensions
Joint Authors
Antonow, M. B.
Lorenzoni, R.
Barbosa, G. M.
Ourique, A. F.
Gomes, P.
Raffin, R. P.
Source
Advances in Materials Science and Engineering
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-16
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Desonide is a topical corticosteroid that has been used for more than 30 years; however, its prolonged use can induce several side effects, affecting dermis and epidermis.
The present work consists of development desonide-loaded nanocapsule suspensions (D-NC) using different polymers (Eudragit S100® or Eudragit L100®) and desonide-loaded lipid-core nanocapsules (D-LNC).
They were formulated by interfacial deposition using the preformed polymer method and all formulations showed negative zeta potential and adequate nanotechnological characteristics (particle size 161–202 nm, polydispersity index < 0.20).
Simple and sensitive methods using high-performance liquid chromatography (HPLC) were developed to quantify desonide in LNC and to study its release kinetics.
The method was linear, specific, precise, and exact and therefore can be applied in quantification of D-NC and D-LNC.
We evaluated in vitro methods for drug release (dissolution, Franz diffusion cells, and dialysis sac) and we use mathematical models (monoexponential, biexponential, and Korsmeyer-Peppas) to show release kinetics from this system.
American Psychological Association (APA)
Antonow, M. B.& Lorenzoni, R.& Barbosa, G. M.& Ourique, A. F.& Gomes, P.& Raffin, R. P.. 2016. Development and Physicochemical Characterization of Desonide-Loaded Nanocapsule Suspensions. Advances in Materials Science and Engineering،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1096375
Modern Language Association (MLA)
Antonow, M. B.…[et al.]. Development and Physicochemical Characterization of Desonide-Loaded Nanocapsule Suspensions. Advances in Materials Science and Engineering No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1096375
American Medical Association (AMA)
Antonow, M. B.& Lorenzoni, R.& Barbosa, G. M.& Ourique, A. F.& Gomes, P.& Raffin, R. P.. Development and Physicochemical Characterization of Desonide-Loaded Nanocapsule Suspensions. Advances in Materials Science and Engineering. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1096375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096375