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Erythropoiesis in Malaria Infections and Factors Modifying the Erythropoietic Response
Joint Authors
Pathak, Vrushali A.
Ghosh, Kanjaksha
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Anemia is the primary clinical manifestation of malarial infections and is responsible for the substantial rate of morbidity.
The pathophysiology discussed till now catalogued several causes for malarial anemia among which ineffective erythropoiesis being remarkable one occurs silently in the bone marrow.
A systematic literature search was performed and summarized information on erythropoietic response upon malaria infection and the factors responsible for the same.
This review summarizes the clinical and experimental studies on patients, mouse models, and in vitro cell cultures reporting erythropoietic changes upon malaria infection as well as factors accountable for the same.
Inadequate erythropoietic response during malaria infection may be the collective effect of various mediators generated by host immune response as well as parasite metabolites.
The interplay between various modulators causing the pathophysiology needs to be explored further.
Globin gene expression profiling upon malaria infection should also be looked into as abnormal production of globin chains could be a possible contributor to ineffective erythropoiesis.
American Psychological Association (APA)
Pathak, Vrushali A.& Ghosh, Kanjaksha. 2016. Erythropoiesis in Malaria Infections and Factors Modifying the Erythropoietic Response. Anemia،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096522
Modern Language Association (MLA)
Pathak, Vrushali A.& Ghosh, Kanjaksha. Erythropoiesis in Malaria Infections and Factors Modifying the Erythropoietic Response. Anemia No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096522
American Medical Association (AMA)
Pathak, Vrushali A.& Ghosh, Kanjaksha. Erythropoiesis in Malaria Infections and Factors Modifying the Erythropoietic Response. Anemia. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096522