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Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties
Joint Authors
Hasan, Md. Sharif
Das, Narhari
Al Mahmud, Zobaer
Abdur Rahman, S. M.
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
The present study was designed to investigate the antinociceptive, anxiolytic, CNS depressant, and hypoglycemic effects of the naproxen metal complexes.
Methods.
The antinociceptive activity was evaluated by acetic acid-induced writhing method and radiant heat tail-flick method while anxiolytic activity was evaluated by elevated plus maze model.
The CNS depressant activity of naproxen metal complexes was assessed using phenobarbitone-induced sleeping time test and the hypoglycemic test was performed using oral glucose tolerance test.
Results.
Metal complexes significantly ( P < 0.001 ) reduced the number of abdominal muscle contractions induced by 0.7% acetic acid solution in a dose dependent manner.
At the dose of 25 mg/kg body weight p.o.
copper, cobalt, and zinc complexes exhibited higher antinociceptive activity having 59.15%, 60.56%, and 57.75% of writhing inhibition, respectively, than the parent ligand naproxen (54.93%).
In tail-flick test, at both doses of 25 and 50 mg/kg, the copper, cobalt, silver, and zinc complexes showed higher antinociceptive activity after 90 minutes than the parent drug naproxen.
In elevated plus maze (EPM) model the cobalt and zinc complexes of naproxen showed significant anxiolytic effects in dose dependent manner, while the copper, cobalt, and zinc complexes showed significant CNS depressant and hypoglycemic activity.
Conclusion.
The present study demonstrated that copper, cobalt, and zinc complexes possess higher antinociceptive, anxiolytic, CNS depressant, and hypoglycemic properties than the parent ligand.
American Psychological Association (APA)
Hasan, Md. Sharif& Das, Narhari& Al Mahmud, Zobaer& Abdur Rahman, S. M.. 2016. Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096616
Modern Language Association (MLA)
Hasan, Md. Sharif…[et al.]. Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties. Advances in Pharmacological and Pharmaceutical Sciences No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1096616
American Medical Association (AMA)
Hasan, Md. Sharif& Das, Narhari& Al Mahmud, Zobaer& Abdur Rahman, S. M.. Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties. Advances in Pharmacological and Pharmaceutical Sciences. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096616
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096616