Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β-Thalassemia Major: A Comprehensive Review in 2015
Joint Authors
Darvishi Khezri, Hadi
Kosaryan, Mehrnoush
Aliasgharian, Aily
Jalali, Hossein
Hadian Amree, Arash
Salehifar, Ebrahim
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Major β-thalassemia (β-TM) is one of the most common inherited hemolytic types of anemia which is caused as a result of absent or reduced synthesis of β-globin chains of hemoglobin.
This defect results in red blood cells lysis and chronic anemia that can be treated by multiple blood transfusions and iron chelation therapy.
Without iron chelation therapy, iron overload will cause lots of complications in patients.
Antioxidant components play an important role in the treatment of the disease.
Silymarin is an antioxidant flavonoid isolated from Silybum marianum plant.
In the present study, we reviewed clinical and experimental studies investigating the use of silymarin prior to September 1, 2015, using PubMed, ISI Web of Knowledge, Science Direct, Scopus, Ovid, and Cochrane Library databases and we evaluated the potential effects of silymarin on controlling the complications induced by iron overload in patients with β-TM.
Based on the results of the present study, we can conclude that silymarin may be useful as an adjuvant for improving multiple organ dysfunctions.
American Psychological Association (APA)
Darvishi Khezri, Hadi& Salehifar, Ebrahim& Kosaryan, Mehrnoush& Aliasgharian, Aily& Jalali, Hossein& Hadian Amree, Arash. 2016. Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β-Thalassemia Major: A Comprehensive Review in 2015. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096617
Modern Language Association (MLA)
Darvishi Khezri, Hadi…[et al.]. Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β-Thalassemia Major: A Comprehensive Review in 2015. Advances in Pharmacological and Pharmaceutical Sciences No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096617
American Medical Association (AMA)
Darvishi Khezri, Hadi& Salehifar, Ebrahim& Kosaryan, Mehrnoush& Aliasgharian, Aily& Jalali, Hossein& Hadian Amree, Arash. Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β-Thalassemia Major: A Comprehensive Review in 2015. Advances in Pharmacological and Pharmaceutical Sciences. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096617