Anti-Parkinson Activity of Petroleum Ether Extract of Ficus religiosa (L.) Leaves
Joint Authors
Bhangale, Jitendra O.
Acharya, Sanjeev R.
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In the present study, we evaluated anti-Parkinson’s activity of petroleum ether extract of Ficus religiosa (PEFRE) leaves in haloperidol and 6 hydroxydopamine (6-OHDA) induced experimental animal models.
In this study, effects of Ficus religiosa (100, 200, and 400 mg/kg, p.o.) were studied using in vivo behavioral parameters like catalepsy, muscle rigidity, and locomotor activity and its effects on neurochemical parameters (MDA, CAT, SOD, and GSH) in rats.
The experiment was designed by giving haloperidol to induce catalepsy and 6-OHDA to induce Parkinson’s disease-like symptoms.
The increased cataleptic scores (induced by haloperidol) were significantly ( p < 0.001 ) found to be reduced, with the PEFRE at a dose of 200 and 400 mg/kg (p.o.).
6-OHDA significantly induced motor dysfunction (muscle rigidity and hypolocomotion).
6-OHDA administration showed significant increase in lipid peroxidation level and depleted superoxide dismutase, catalase, and reduced glutathione level.
Daily administration of PEFRE (400 mg/kg) significantly improved motor performance and also significantly attenuated oxidative damage.
Thus, the study proved that Ficus religiosa treatment significantly attenuated the motor defects and also protected the brain from oxidative stress.
American Psychological Association (APA)
Bhangale, Jitendra O.& Acharya, Sanjeev R.. 2016. Anti-Parkinson Activity of Petroleum Ether Extract of Ficus religiosa (L.) Leaves. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096637
Modern Language Association (MLA)
Bhangale, Jitendra O.& Acharya, Sanjeev R.. Anti-Parkinson Activity of Petroleum Ether Extract of Ficus religiosa (L.) Leaves. Advances in Pharmacological and Pharmaceutical Sciences No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1096637
American Medical Association (AMA)
Bhangale, Jitendra O.& Acharya, Sanjeev R.. Anti-Parkinson Activity of Petroleum Ether Extract of Ficus religiosa (L.) Leaves. Advances in Pharmacological and Pharmaceutical Sciences. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096637
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096637